中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
z1期
22-25
,共4页
安琳琳%盛春元%韩铁云%马启武%尹聪
安琳琳%盛春元%韓鐵雲%馬啟武%尹聰
안림림%성춘원%한철운%마계무%윤총
愈伤灵胶囊%三七皂苷R1%人参皂苷Rg1%人参皂苷Rb1%色谱法,高效液相
愈傷靈膠囊%三七皂苷R1%人參皂苷Rg1%人參皂苷Rb1%色譜法,高效液相
유상령효낭%삼칠조감R1%인삼조감Rg1%인삼조감Rb1%색보법,고효액상
Yushangling capsule%Notoginsenoside R1%Ginsenoside Rg1%Ginsenoside Rb1%Chromatography,high pressure liquid
目的 研究愈伤灵胶囊中三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的含量测定方法,为制定质量标准中含量测定方法及含量限度提供依据.方法 用岛津WondaSil C18色谱柱、乙腈-水梯度洗脱,0~12min(19∶81),12~60 min(19∶81→36∶64),60~71 min(36∶64→19∶81),流速:1.0ml·min-1,检测波长:203 nm,柱温:30℃.结果 三七皂苷R1在0.0996~1.9920 μg范围内呈良好的线性关系(r=0.999997),平均回收率为99.9683%,相对标准差为1.3561%;人参皂苷Rg1在0.4244~8.4880 μg范围内呈良好的线性关系(r=0.999998),平均回收率为99.9417%,相对标准差为0.2706%;人参皂苷Rb1在0.3923~ 7.8460μg范围内呈良好的线性关系(r=0.999998),平均回收率为99.3933%,相对标准差为0.7303%.结论 该方法简便、快速、重现性好,准确可靠,可作为愈伤灵胶囊的质量控制方法.
目的 研究愈傷靈膠囊中三七皂苷R1、人參皂苷Rg1、人參皂苷Rb1的含量測定方法,為製定質量標準中含量測定方法及含量限度提供依據.方法 用島津WondaSil C18色譜柱、乙腈-水梯度洗脫,0~12min(19∶81),12~60 min(19∶81→36∶64),60~71 min(36∶64→19∶81),流速:1.0ml·min-1,檢測波長:203 nm,柱溫:30℃.結果 三七皂苷R1在0.0996~1.9920 μg範圍內呈良好的線性關繫(r=0.999997),平均迴收率為99.9683%,相對標準差為1.3561%;人參皂苷Rg1在0.4244~8.4880 μg範圍內呈良好的線性關繫(r=0.999998),平均迴收率為99.9417%,相對標準差為0.2706%;人參皂苷Rb1在0.3923~ 7.8460μg範圍內呈良好的線性關繫(r=0.999998),平均迴收率為99.3933%,相對標準差為0.7303%.結論 該方法簡便、快速、重現性好,準確可靠,可作為愈傷靈膠囊的質量控製方法.
목적 연구유상령효낭중삼칠조감R1、인삼조감Rg1、인삼조감Rb1적함량측정방법,위제정질량표준중함량측정방법급함량한도제공의거.방법 용도진WondaSil C18색보주、을정-수제도세탈,0~12min(19∶81),12~60 min(19∶81→36∶64),60~71 min(36∶64→19∶81),류속:1.0ml·min-1,검측파장:203 nm,주온:30℃.결과 삼칠조감R1재0.0996~1.9920 μg범위내정량호적선성관계(r=0.999997),평균회수솔위99.9683%,상대표준차위1.3561%;인삼조감Rg1재0.4244~8.4880 μg범위내정량호적선성관계(r=0.999998),평균회수솔위99.9417%,상대표준차위0.2706%;인삼조감Rb1재0.3923~ 7.8460μg범위내정량호적선성관계(r=0.999998),평균회수솔위99.3933%,상대표준차위0.7303%.결론 해방법간편、쾌속、중현성호,준학가고,가작위유상령효낭적질량공제방법.
Objective To establish an assay method for notoginsenside R1,ace ginsenoside Rg1 and Rb1 in yushangling capsule.Medthods C18 column was used with a mobile phase of acetonitrile-water 0-12 min( 19∶81 ),12-60 min( 19∶81→36∶64),60-71 min( 36∶64→19∶81 ) gradient elution,velocity of flow:1.0 ml · min -1 ;Column temperature:30 ℃ ; The wavelength of detecter was set at 203 nm.Results The linear range of ginsenoside R1,ginsenoside Rg1 and Rb1 was 0.0996-1.9920 μg,0.4244-8.4880 μg and 0.3923-7.8460 μg,respectively,the average recovery rate was 99.9683% [ relative standard deviation (RSD) =1.3561% ],99.9417% ( RSD =0.2706% ) and 99.3933% ( RSD =0.7303% ),respectively.Conclusion The method is rapid,accurate,sensitive and reliable.The results show that the method can be used to control quality of products.