中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
5期
550-551
,共2页
房辉%裴玉梅%张雅中%田金莉%房景霞%张禾伟%许静%吴卫平
房輝%裴玉梅%張雅中%田金莉%房景霞%張禾偉%許靜%吳衛平
방휘%배옥매%장아중%전금리%방경하%장화위%허정%오위평
甲状腺功能减退症%过氧化损伤%心脏%Na+-K+-ATP交换酶
甲狀腺功能減退癥%過氧化損傷%心髒%Na+-K+-ATP交換酶
갑상선공능감퇴증%과양화손상%심장%Na+-K+-ATP교환매
Hypothyroidism%Peroxidative damage%Heart%Na+-K+-exchanging ATPase
采用低碘饮食建立甲状腺功能减退(甲减)动物模型,观察心肌抗氧化能力及Na+-K+-ATP酶α1亚基mRNA的变化,结果显示甲减大鼠心肌抗氧化能力下降,导致心肌过氧化损伤,心肌细胞萎缩,心脏内膜软骨化生,膜上参与代谢的ATP酶活性降低,Na+-K+-ATP酶α1亚基mRNA的表达下降.
採用低碘飲食建立甲狀腺功能減退(甲減)動物模型,觀察心肌抗氧化能力及Na+-K+-ATP酶α1亞基mRNA的變化,結果顯示甲減大鼠心肌抗氧化能力下降,導緻心肌過氧化損傷,心肌細胞萎縮,心髒內膜軟骨化生,膜上參與代謝的ATP酶活性降低,Na+-K+-ATP酶α1亞基mRNA的錶達下降.
채용저전음식건립갑상선공능감퇴(갑감)동물모형,관찰심기항양화능력급Na+-K+-ATP매α1아기mRNA적변화,결과현시갑감대서심기항양화능력하강,도치심기과양화손상,심기세포위축,심장내막연골화생,막상삼여대사적ATP매활성강저,Na+-K+-ATP매α1아기mRNA적표체하강.
The antioxidative capability and Na+-K+-ATPase α1-subunit mRNA expression in myocardium of hypothyroid rats induced by low-iodine diet were observed. The results showed that the antioxidative capability of myocardium decreased, resulting in lipid peroxidative damage, atrophy of myocardial cells and chondrification of tunica intima, along with decreased expression of sodium pump α1 subunit mRNA in hypothyroid rats.
