国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
7期
606-609
,共4页
肝郁肾虚%女性抑郁%性激素%中药
肝鬱腎虛%女性抑鬱%性激素%中藥
간욱신허%녀성억욱%성격소%중약
Stagnation of liver-qi and kidney deficiency%Female depression%Sex hormone%Traditional Chinese medicine
目的 探讨肾虚肝郁型女性抑郁症患者性激素水平变化及中药的干预情况.方法 选择2007年3月至2011年3月符合CCMD-3、ICD-10中抑郁发作诊断标准和中医辨证标准的120例患者,按年龄病情等因素运用分层随机分组法分为两组各60例.治疗组口服具有补肾疏肝功效的中药治疗,对照组口服帕罗西汀,两组患者均治疗12周.同时另设健康组60例,于治疗结束时进行HAMD评分和中医症状评分比较,观察血清雌二醇(E2)、孕酮(P)、催乳素(PRL)的变化.结果 治疗后,治疗组E2水平升高、PRL水平下降,与同组治疗前比较,差异有统计学意义[E2治疗前=(103.6±28.24) pmol/L,E2治疗后=(167.7±30.46)pmol/L; PRL治疗前=(32.5±7.61) μg/L,PRL治疗后=(15.3±5.92) μg/L,P均＜0.01]；与健康组比较,差异无统计学意义[E2健康组=(176.3±33.63) pmol/L,PRL健康组=(12.7±5.23)μg/L,P均＞0.05)].对照组治疗后E2水平虽较同组治疗前升高[E2治疗前=(101.3±27.18)pmol/L,E2治疗后=(142.1±30.11 )pmol/L,P＜0.01],但与健康组比较,差异有统计学意义[E2健康组=(176..3±33.63) pmol/L,P＜0.01].结论 疏肝益肾法可有效干预抑郁症患者性激素分泌水平,改善患者的抑郁症状.
目的 探討腎虛肝鬱型女性抑鬱癥患者性激素水平變化及中藥的榦預情況.方法 選擇2007年3月至2011年3月符閤CCMD-3、ICD-10中抑鬱髮作診斷標準和中醫辨證標準的120例患者,按年齡病情等因素運用分層隨機分組法分為兩組各60例.治療組口服具有補腎疏肝功效的中藥治療,對照組口服帕囉西汀,兩組患者均治療12週.同時另設健康組60例,于治療結束時進行HAMD評分和中醫癥狀評分比較,觀察血清雌二醇(E2)、孕酮(P)、催乳素(PRL)的變化.結果 治療後,治療組E2水平升高、PRL水平下降,與同組治療前比較,差異有統計學意義[E2治療前=(103.6±28.24) pmol/L,E2治療後=(167.7±30.46)pmol/L; PRL治療前=(32.5±7.61) μg/L,PRL治療後=(15.3±5.92) μg/L,P均＜0.01]；與健康組比較,差異無統計學意義[E2健康組=(176.3±33.63) pmol/L,PRL健康組=(12.7±5.23)μg/L,P均＞0.05)].對照組治療後E2水平雖較同組治療前升高[E2治療前=(101.3±27.18)pmol/L,E2治療後=(142.1±30.11 )pmol/L,P＜0.01],但與健康組比較,差異有統計學意義[E2健康組=(176..3±33.63) pmol/L,P＜0.01].結論 疏肝益腎法可有效榦預抑鬱癥患者性激素分泌水平,改善患者的抑鬱癥狀.
목적 탐토신허간욱형녀성억욱증환자성격소수평변화급중약적간예정황.방법 선택2007년3월지2011년3월부합CCMD-3、ICD-10중억욱발작진단표준화중의변증표준적120례환자,안년령병정등인소운용분층수궤분조법분위량조각60례.치료조구복구유보신소간공효적중약치료,대조조구복파라서정,량조환자균치료12주.동시령설건강조60례,우치료결속시진행HAMD평분화중의증상평분비교,관찰혈청자이순(E2)、잉동(P)、최유소(PRL)적변화.결과 치료후,치료조E2수평승고、PRL수평하강,여동조치료전비교,차이유통계학의의[E2치료전=(103.6±28.24) pmol/L,E2치료후=(167.7±30.46)pmol/L; PRL치료전=(32.5±7.61) μg/L,PRL치료후=(15.3±5.92) μg/L,P균＜0.01]；여건강조비교,차이무통계학의의[E2건강조=(176.3±33.63) pmol/L,PRL건강조=(12.7±5.23)μg/L,P균＞0.05)].대조조치료후E2수평수교동조치료전승고[E2치료전=(101.3±27.18)pmol/L,E2치료후=(142.1±30.11 )pmol/L,P＜0.01],단여건강조비교,차이유통계학의의[E2건강조=(176..3±33.63) pmol/L,P＜0.01].결론 소간익신법가유효간예억욱증환자성격소분비수평,개선환자적억욱증상.
Objective To study the changes of sex hormone levels and the intervention of Chinese medicine female depression patients of kidney deficiency and liver depression type.Methods According to CCMD-3 and ICD-10 depressive episodes diagnostic criteria and the Chinese medicine dialectical criteria,120 patients from March 2007 to March 2011 were selccted and randomly recruited into a treatment group (n=60) and a control group (n=60),respectively.The treatment group was treated with traditional Chinese medicine with the functions of tonifying kidney and soothing liver,while the control group was treated with paroxetine.Both groups were treated for 12 weeks.Another healthy group of 60 cases was also setup.HAMD score and symptom score were used to observe the curative effects,the changes of E2,P,and PRL were observed in the patients and healthy persons.Results In the treatment group:E2 levels increased,PRL decreased,compared with the same group before treatment,the difference was statistically significant,[before treatment,E2=(103.6±28.24)pmol/L,after treatment,E2=(167.7± 30.46)pmol/L,P＜0.01; before treatment,PRL=(32.5 ±7.61)μg/L,after treatment,PRL=(15.3±5.92)μg/L,P＜0.01],Compared with the healthy group,the difference was not statistically significant,[healthy group E2=(176.3±33.63) pmol/L,PRL=(12.7±5.23) μg/L,P＞0.05) ].Although the E2 level of the control group after treatment was significantly elevated than the same group before the treatment [before treatment E2=(101.3±27.18)pmol/L,after treatment E2=(142.1 ±30.11)pmol/L,P＜0.01 ],but compared with healthy controls,the differences were statistically significant [healthy group E2=(176.3±33.63)pmol/L,P＜0.01].Conclusion The method of tonifying kidney and soothing liver has effective interventions on sex hormone secretion in depression patients and improvement in patients with depressive mood.
