CAJ | 학술논문

目的观察尿激酶对血液透析患者动静脉内瘘血栓进行溶栓的疗效,探讨简单、安全、有效的溶栓方法.方法回顾性分析本中心23例患者43例次局部注射尿激酶治疗动静脉内瘘血栓形成资料,比较溶栓前后的部分凝血活酶活化时间(APTT)、纤维蛋白原(Fbg)、国际标准化比值(INR)、凝血酶原时间(PT)、凝血酶时间(TT).结果 23例患者共行43例次溶栓治疗,成功33例次占76.7%,未见不良反应.溶栓治疗与血栓形成的时间有关,与年龄、透析年限及内瘘使用时间无关,溶栓前后APTT、Fbg、INR、PT、TT差异无统计学意义.结论尿激酶对动静脉内瘘溶栓治疗操作简单,创伤小,成功率较高,不良反应少,有较高的临床应用价值.
목적 관찰뇨격매대혈액투석환자동정맥내루혈전진행용전적료효,탐토간단、안전、유효적용전방법.방법 회고성분석본중심23례환자43례차국부주사뇨격매치료동정맥내루혈전형성자료,비교용전전후적부분응혈활매활화시간(APTT)、섬유단백원(Fbg)、국제표준화비치(INR)、응혈매원시간(PT)、응혈매시간(TT).결과 23례환자공행43례차용전치료,성공33례차점76.7%,미견불량반응.용전치료여혈전형성적시간유관,여년령、투석년한급내루사용시간무관,용전전후APTT、Fbg、INR、PT、TT차이무통계학의의.결론 뇨격매대동정맥내루용전치료조작간단,창상소,성공솔교고,불량반응소,유교고적림상응용개치.
Objective To observe the effects of urokinase in the treatment of thrombosis in hemodialysis patients with arteriovenous fistulae and to discuss simple, safe and effective methods of thrombolysis. Methods Local injections of urokinase were applied in 23 hemodialysis patients for 43 times to treat thrombosis in fistula, then the effects were observed, and the changes between before treatment and after treatment of several index, such as activated partial thromboplastin time( APTT), Fibrinogen( Fbg), international normalized ratio (INR), Prothrombin Time (PT), thrombin time(TT) were compared. Results The thrombolytic therapies were used in 23 cases for 43 times in total, in which 33 times (76.7% ) received success, and there were no severe complications occurred. The effectiveness was related to the duration of thrombosis. There were no significant differences in comparison of APTT, Fbg, INR, PT, TT before and after urokinase administration. Conclusions Urokinase was effective in thrombolytic therapy for hemodialysis patients with thrombosis in arteriovenous fistula.