中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2011年
11期
1106-1109
,共4页
杨晨%陈磊%常晓赞%葛顺楠%朱俊玲%高国栋
楊晨%陳磊%常曉讚%葛順楠%硃俊玲%高國棟
양신%진뢰%상효찬%갈순남%주준령%고국동
氯丙嗪%HVSs节律%脑电图%肌电图
氯丙嗪%HVSs節律%腦電圖%肌電圖
록병진%HVSs절률%뇌전도%기전도
Chlorpromazine%High-voltage spindle%EEG%Electromyography
目的 探讨氯丙嗪对正常成年大鼠自由活动状态下皮层HVSs节律以及面部抽搐的影响.方法 通过在体多通道电生理记录技术结合视频录像,对可自由活动的正常大鼠进行皮层脑电和面部肌电长程记录,观察大鼠腹腔注射氯丙嗪后皮层HVSs节律个数、持续时间以及HVSs出现期间面部活动及肌电的变化.结果 大鼠清醒静止状态下自发出现HVSs节律,面部偶发抽搐,腹腔注射低剂量氯丙嗪(1.5 mg/kg)和高剂量氯丙嗪(3.0 mg/kg)后均使HVSs节律个数增加,持续时间延长,大鼠面部肌肉节律性活动增多、持续时间延长.结论 氯丙嗪能增强生理状态下出现的HVSs节律及面部抽搐,提示抗精神病药物锥体外系副作用可能与HVSs节律有关,而多巴胺受体可能参与大鼠皮层HVSs节律的调控.
目的 探討氯丙嗪對正常成年大鼠自由活動狀態下皮層HVSs節律以及麵部抽搐的影響.方法 通過在體多通道電生理記錄技術結閤視頻錄像,對可自由活動的正常大鼠進行皮層腦電和麵部肌電長程記錄,觀察大鼠腹腔註射氯丙嗪後皮層HVSs節律箇數、持續時間以及HVSs齣現期間麵部活動及肌電的變化.結果 大鼠清醒靜止狀態下自髮齣現HVSs節律,麵部偶髮抽搐,腹腔註射低劑量氯丙嗪(1.5 mg/kg)和高劑量氯丙嗪(3.0 mg/kg)後均使HVSs節律箇數增加,持續時間延長,大鼠麵部肌肉節律性活動增多、持續時間延長.結論 氯丙嗪能增彊生理狀態下齣現的HVSs節律及麵部抽搐,提示抗精神病藥物錐體外繫副作用可能與HVSs節律有關,而多巴胺受體可能參與大鼠皮層HVSs節律的調控.
목적 탐토록병진대정상성년대서자유활동상태하피층HVSs절률이급면부추휵적영향.방법 통과재체다통도전생리기록기술결합시빈록상,대가자유활동적정상대서진행피층뇌전화면부기전장정기록,관찰대서복강주사록병진후피층HVSs절률개수、지속시간이급HVSs출현기간면부활동급기전적변화.결과 대서청성정지상태하자발출현HVSs절률,면부우발추휵,복강주사저제량록병진(1.5 mg/kg)화고제량록병진(3.0 mg/kg)후균사HVSs절률개수증가,지속시간연장,대서면부기육절률성활동증다、지속시간연장.결론 록병진능증강생리상태하출현적HVSs절률급면부추휵,제시항정신병약물추체외계부작용가능여HVSs절률유관,이다파알수체가능삼여대서피층HVSs절률적조공.
Objective To explore the effect of chlorpromazine on neocortical high-voltage spindles(HVSs)and facial twitching in freely moving normal adult rats.Methods Continuous video,neocortical electroencephalogram(EEG)and facial electromyography(EMG)were recorded simultaneously for at least 6 h in freely moving rats.The number and mean duration of HVSs,and the facial muscular activity were analyzed after administration of chlorpromazine.Results HVSs spontaneously appeared in behavioral waking-immobility rats with accidental hyperspasmia.After rats being administrated with chlorpromazine at a dose of 1.5(mg/kg)and 3.0(mg/kg),the facial rhythmic muscular activity increased,the duration of rhythmic muscular activity prolonged,the number of HVSs increased and the mean duration of HVSs prolonged.Conclusion Chlorpromazine could enhance the physiological HVSs and facial twitching,indicating that the side effect at the extrapyramidal system of antipsychotic maybe relate to HVSs and dopamine receptor may contribute to the regulation of HVSs.
