CAJ | 학술논문

目的探讨花生四烯酸5-脂氧合酶激活蛋白(arachidonate 5-lipoxygenase acttvating protein,ALOX5AP)基因SG13S114 A/T的多态性与颈动脉粥样硬化斑块稳定程度的关系.方法应用聚合酶链反应-限制性片段长度多态性分析法检测132例颈动脉易损斑块及152例稳定斑块的急性脑梗死者ALOX5AP基因SG13S114 A/T基因型,比较两组间该位点多态性的差异.结果易损斑块组ALOX5AP基因SG13S114 AA基因型和A等位基因频率高于稳定斑块组,两组差异有统计学意义(P＜0.01),其中男性和女性上述基因型和等位基因频率的比较,易损斑块组均高于稳定斑块组,两组差异有统计学意义(P＜0.01).结论 ALOX5AP基因SG13S114 A/T多态性可能与动脉粥样斑块的稳定性有关,其中SG13S114 A等位基因可能是易损斑块的风险因素.
목적 탐토화생사희산5-지양합매격활단백(arachidonate 5-lipoxygenase acttvating protein,ALOX5AP)기인SG13S114 A/T적다태성여경동맥죽양경화반괴은정정도적관계.방법 응용취합매련반응-한제성편단장도다태성분석법검측132례경동맥역손반괴급152례은정반괴적급성뇌경사자ALOX5AP기인SG13S114 A/T기인형,비교량조간해위점다태성적차이.결과 역손반괴조ALOX5AP기인SG13S114 AA기인형화A등위기인빈솔고우은정반괴조,량조차이유통계학의의(P＜0.01),기중남성화녀성상술기인형화등위기인빈솔적비교,역손반괴조균고우은정반괴조,량조차이유통계학의의(P＜0.01).결론 ALOX5AP기인SG13S114 A/T다태성가능여동맥죽양반괴적은정성유관,기중SG13S114 A등위기인가능시역손반괴적풍험인소.
Objective To investigate the relationship between the polymorphism of SG13S114 A/T in the 5-lipoxygenase-activating protein (ALOX5AP)gene and the stability of carotid atherosclerosis. Methods Polymorphism of SG13S114 A/T in the ALOX5AP gene was analyzed in 152 cases of acute infarction with stable plaque, and 132 cases of acute infarction with vulnerable plaques, by using polymerase chain reaction and restriction fragment length polymorphism. Carotid artery plaque was analyzed by carotid artery color ultrasound. Results The frequencies of SG13S114 AA genotype and the A allele in the vulnerable plaque group were higher than that in the stable plaque group (P＜0.01). Conclusion The polymorphism of SG13S114 A/T in the ALOX5AP gene may be associated with the instability of atherosclerosis. And the SG13S114 A allele may be a risk factor of vulnerable plaques.