CAJ | 학술논문

目的探讨t(11；18)(q21；q21)染色体易位对于胃黏膜相关淋巴组织(mucosal associated lymphoid tissue,MALT)淋巴瘤预后意义.方法采用回顾性方法对1994年1月至2004年6月间,经术后病理明确诊断的36例MALT淋巴瘤患者进行随访,同时采用间期荧光原位杂交技术检测患者保存的石蜡手术标本有无t(11；18)(q21；q21)染色体易位.结果 36例患者中15例检出t(11;18)(q21；q21)染色体易位,阳性率为41.67％;35例随访至2010年3月,总的中位生存期87个月,伴有t(11;18)(q21；q21)染色体易位者的中位生存期为43个月,无t(11；18)(q21；q21)染色体易位者的中位生存期为130个月,两组之间差异有统计学意义(x2 =29.57,P＜0.01).结论 t(11；18)(q21；q21)染色体易位是MALT淋巴瘤的重要预后因素.
목적 탐토t(11；18)(q21；q21)염색체역위대우위점막상관림파조직(mucosal associated lymphoid tissue,MALT)림파류예후의의.방법 채용회고성방법대1994년1월지2004년6월간,경술후병리명학진단적36례MALT림파류환자진행수방,동시채용간기형광원위잡교기술검측환자보존적석사수술표본유무t(11；18)(q21；q21)염색체역위.결과 36례환자중15례검출t(11;18)(q21；q21)염색체역위,양성솔위41.67％;35례수방지2010년3월,총적중위생존기87개월,반유t(11;18)(q21；q21)염색체역위자적중위생존기위43개월,무t(11；18)(q21；q21)염색체역위자적중위생존기위130개월,량조지간차이유통계학의의(x2 =29.57,P＜0.01).결론 t(11；18)(q21；q21)염색체역위시MALT림파류적중요예후인소.
Objective To investigate the prognostic value of t(11;18)(q21;q21)in gastric mucosa-associated lymphoid tissue lymphoma.Methods A cohort of thirty-six gastric mucosa-associated lymphoid tissue lymphoma patients who were pathologically identify diagnosis from January 1994 to June 2004 were followed up retrospectively and studied using fluorescence in situ hybridization(FISH) technique to detect t(11;18) (q21;q21) chromosomal translocation on preservative paraffin specimen.Results Among thirty-six patients,fifteen (41.67％) were positive for t(11;18) (q21;q21).All but one were followed up to March 2010,general median survival time (MST) was 87 months.The MST were 43 and 130 months for t(11;H8) positive and negative patients,respectively.The MST between these two groups was notably different (x2 =29.57,P＜0.01).Conclusion t(11;18) (q21;q21) is important prognostic factor for gastric mucosa-associated lymphoid tissue lymphoma.