CAJ | 학술논문

课题分临床与实验研究两部分,临床按住院顺序选120例心衰患者,随机分为治疗组与对照组,实验研究以心衰大鼠模型为对象,并分别对其临床疗效、血液动力学、心钠素(ANP)、氧自由基及动物心、肝、肺脏的病理切片进行了细胞形态学观察。结果表明,康心力胶囊可以明显提高心衰患者及模型的超氧化物歧化酶(SOD)、谷胱苷肽酶(GSH-Px)、ANP的活性、降低丙二醛(MDA)的含量、提高心输出量(CO)、心博量(SV)(P＜0.05,或P＜0.01)。能明显减轻心衰大鼠模型心、肝、肺脏的瘀血、水肿。临床治疗组显效、有效率均高于对照组(P＜0.05),提示康心力胶囊有显著的抗心衰疗效。
과제분림상여실험연구량부분,림상안주원순서선120례심쇠환자,수궤분위치료조여대조조,실험연구이심쇠대서모형위대상,병분별대기림상료효、혈액동역학、심납소(ANP)、양자유기급동물심、간、폐장적병리절편진행료세포형태학관찰。결과표명,강심력효낭가이명현제고심쇠환자급모형적초양화물기화매(SOD)、곡광감태매(GSH-Px)、ANP적활성、강저병이철(MDA)적함량、제고심수출량(CO)、심박량(SV)(P＜0.05,혹P＜0.01)。능명현감경심쇠대서모형심、간、폐장적어혈、수종。림상치료조현효、유효솔균고우대조조(P＜0.05),제시강심력효낭유현저적항심쇠료효。
Clinical therapeutic effect,hemodynamics,and contents of atrialnatriuretic polypeptide(ANP) and oxygen free radicals,and cytomorphologic observation of the heart,liver and lung were investigated respectively in model rats of heart failure and 120 cases of heart failure who were randomly assigned to treatment group and control group.Results indicate that Kang Xin Li Capsule can increase obviously activities of superoxide dismutase (SOD) and glutathione reductase(GSH-Px) and content of ANP, and reduce level of malondiadehyde(MDA),raise cardiac output(CO) and stroke volume(SV)(P<0.05 or P<0.01); and it can relieve obviously blood stasis and edema of the heart,liver and lung.Both the markedly effective rate and the effective rate in the clinical treatment group are higher than those in the control group(P<0.05),suggesting that Kang Xin Li Capsule has obvious anti-heart-failure action.