CAJ | 학술논문

目的利用大鼠模型研究糖尿病(DM)对尿道外括约肌功能的影响.方法以雌性SD大鼠制成DM模型,6～8周后测定DM大鼠和正常对照(NC)大鼠膀胱等容收缩状态下的膀胱内压、尿道充盈压和括约肌肌电图(EUS-EMG).结果与NC大鼠对比,DM大鼠体重明显降低,血糖明显升高,膀胱容量明显增大;膀胱排尿收缩时尿道压力病理性增高;EUS-EMG表现为排尿过程中应有的尿道外括约肌高频舒张收缩减弱或消失,引发的尿道压力曲线上的高频振动波振幅降低或消失.结论 DM在损伤大鼠膀胱功能的同时,还损伤排尿时尿道外括约肌正常的高频收缩舒张功能.
목적 이용대서모형연구당뇨병(DM)대뇨도외괄약기공능적영향.방법이자성SD대서제성DM모형,6～8주후측정DM대서화정상대조(NC)대서방광등용수축상태하적방광내압、뇨도충영압화괄약기기전도(EUS-EMG).결과 여NC대서대비,DM대서체중명현강저,혈당명현승고,방광용량명현증대;방광배뇨수축시뇨도압력병이성증고;EUS-EMG표현위배뇨과정중응유적뇨도외괄약기고빈서장수축감약혹소실,인발적뇨도압력곡선상적고빈진동파진폭강저혹소실.결론 DM재손상대서방광공능적동시,환손상배뇨시뇨도외괄약기정상적고빈수축서장공능.
Objective Urethral function is essential for efficient voiding.This study focused on the function of the external urethral sphincter (EUS) in DM rats. Methods Female SD rats with the weight of 250-275g weight initially were used.DM (n=6) was induced by an i.p.injection of streptozotocin (65 mg/kg) and allowed to progress for 6 to 8 weeks,and age-matched normal rats (n=5) were taken as control.A double lumen catheter was used to simultaneously record isovolumetric bladder pressure and urethral perfusion pressure (UPP) under urethane anesthesia.EUS-EMG(electromyogram) activities were also recorded using fine wired electrodes. Results Blood glucose of all DM rats was>300 mg/dl.High frequency oscillations (HFOs) of UPP were significantly reduced in some diabetic rats, but never in controls.The increased tonic EUS activity in diabetic rats resulted in increased urethral resistance (UPP was 23.5±1.6mmHg in DM rats compared with 7.9±1.8mmHg in controls,P<0.05). Conclusions These results demonstrate that DM induces EUS dysfunctions, decreases urethral relaxation and increases urethral outlet resistance during reflex voiding