临床医学
臨床醫學
림상의학
CLINICAL MEDICINE
2009年
2期
14-16
,共3页
冠状动脉硬化%普伐他汀%冠状动脉血管造影%双源螺旋CT%动脉硬化斑块
冠狀動脈硬化%普伐他汀%冠狀動脈血管造影%雙源螺鏇CT%動脈硬化斑塊
관상동맥경화%보벌타정%관상동맥혈관조영%쌍원라선CT%동맥경화반괴
Coronary arteriosclerosis%Pravastatin%Dual source spiral CT%CT coronary artery imaging%Artery plaque
目的 观察强化降脂治疗对冠状动脉粥样斑块的影响,比较不同他汀类药物作用的差别.方法 将74例经双源螺旋CT血管造影确诊的冠状动脉粥样斑块患者,随机分为治疗组和对照组,各37例,分别给予普伐他汀20 mg/d和洛伐他汀20 mg/d口服,12个月后复查冠脉CTA观察斑块变化.结果 治疗组总胆固醇、低密度胆固醇治疗后分别下降31.5%、42.6%,与对照组相比差异有统计学意义(P<0.05).两组患者共发现175个粥样斑块,导致126支冠状动脉不同程度狭窄.治疗组脂质斑块、纤维斑块、混合斑块引起的冠脉狭窄分别减少23.7%、15.4%、12.5%,较对照组下降更明显(P<0.05);两组钙化斑块引起的冠脉狭窄分别下降3.6%、2.8%,差异均无统计学意义(P>0.05).结论 普伐他汀可有效降低胆固醇,能明显逆转冠脉粥样斑块,降低冠脉狭窄程度.
目的 觀察彊化降脂治療對冠狀動脈粥樣斑塊的影響,比較不同他汀類藥物作用的差彆.方法 將74例經雙源螺鏇CT血管造影確診的冠狀動脈粥樣斑塊患者,隨機分為治療組和對照組,各37例,分彆給予普伐他汀20 mg/d和洛伐他汀20 mg/d口服,12箇月後複查冠脈CTA觀察斑塊變化.結果 治療組總膽固醇、低密度膽固醇治療後分彆下降31.5%、42.6%,與對照組相比差異有統計學意義(P<0.05).兩組患者共髮現175箇粥樣斑塊,導緻126支冠狀動脈不同程度狹窄.治療組脂質斑塊、纖維斑塊、混閤斑塊引起的冠脈狹窄分彆減少23.7%、15.4%、12.5%,較對照組下降更明顯(P<0.05);兩組鈣化斑塊引起的冠脈狹窄分彆下降3.6%、2.8%,差異均無統計學意義(P>0.05).結論 普伐他汀可有效降低膽固醇,能明顯逆轉冠脈粥樣斑塊,降低冠脈狹窄程度.
목적 관찰강화강지치료대관상동맥죽양반괴적영향,비교불동타정류약물작용적차별.방법 장74례경쌍원라선CT혈관조영학진적관상동맥죽양반괴환자,수궤분위치료조화대조조,각37례,분별급여보벌타정20 mg/d화락벌타정20 mg/d구복,12개월후복사관맥CTA관찰반괴변화.결과 치료조총담고순、저밀도담고순치료후분별하강31.5%、42.6%,여대조조상비차이유통계학의의(P<0.05).량조환자공발현175개죽양반괴,도치126지관상동맥불동정도협착.치료조지질반괴、섬유반괴、혼합반괴인기적관맥협착분별감소23.7%、15.4%、12.5%,교대조조하강경명현(P<0.05);량조개화반괴인기적관맥협착분별하강3.6%、2.8%,차이균무통계학의의(P>0.05).결론 보벌타정가유효강저담고순,능명현역전관맥죽양반괴,강저관맥협착정도.
Objective To observe the influence of intensified blood lipid reduction on coronary artery plaque,and compare the differences between pravastatin and lovastatin.Methods Seventy-four cases of coronary artery atheromatous plaque examined with dual source spiral CT were randomly allocated into two groups:treatment group and control group.Treatment group given pravastatin 20 mg/d and control group given lovastatin 20 mg/d.The changes of plaque and blood lipid were observed after 12 months.Results The TC and LDL-C of the treatment groups induced 31.5% and 42.6%.And the treatment group induced greater than the control gruop(P<0.05).175 plaques observed in 126 coronary artery branches.The coronary artery stenosis caused by all plaques have different degrees of descent after the treatment.The descent rate of the treatment group was 13.7% in lipoid plaques(P<0.01),15.4% in fibrous plaques(P<0.05),12.5% in mixed plaques(P<0.05),3.6% in calcified plaques(P>0.05).The treatment group induced greater(P<0.05).Conclusion Pravastatin can reduce blood lipid markly,reverse and stabilize the coronary artery plaque.
