心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2012年
1期
9-13
,共5页
徐锦春%陈思娇%张浩%齐国先%李廷富%陈婕%高阳%宋今丹
徐錦春%陳思嬌%張浩%齊國先%李廷富%陳婕%高暘%宋今丹
서금춘%진사교%장호%제국선%리정부%진첩%고양%송금단
糖尿病肾病%白蛋白尿%危险因素
糖尿病腎病%白蛋白尿%危險因素
당뇨병신병%백단백뇨%위험인소
Diabetic nephropathies%Albuminuria%Risk factors
目的:探讨影响糖尿病肾病的相关危险因素.方法:入选明确诊断2型糖尿病患者238例,根据尿微量白蛋白/尿肌酐的比值(UACR)分为糖尿病无肾病组(糖尿病1组,90例),早期糖尿病肾病组(糖尿病2组,73例),临床糖尿病肾病组(糖尿病3组,75例),收集所有患者的临床资料,并检测餐前及餐后2h血糖(FBG、2hPB),血脂、尿酸(UA)、纤维蛋白原(Fg)、糖化血红蛋白(HbA1c)等生化指标,并分析其与糖尿病肾病的相关性.结果:糖尿病1组、糖尿病2组、糖尿病3组的糖尿病病程[(7.25±6.29)年比(10.25±7.67)年比(13.53±7.82)年]、FBG[(8.46±2.52) mmol/L比(9.52±3.38) mmol/L比(10.82±3.30) mmol/L]、2hPB(18.40±5.64) mmol/L比(20.27±5.94) mmol/L比(22.59±6.14) mmol/L]、HbA1c[(7.96±1.65)％比(8.60±1.76)％比(9.55±2.09)％]、甘油三酯[(1.72±0.86) mmol/L比(2.34±1.87) mmol/L比(3.16±1.85) mmol/L]、Fg[(3.49±0.93) g/L比(3.88±1.21) g/L比(4.99±2.10) g/L]、UA [(295.42±52.34)μmol/L比(324.18±96.29) μmol/L比(351.23±56.88)μmol/L]水平逐渐显著升高(P＜0.05～＜0.01). Logistic逐步回归分析显示,糖尿病病程、HbA1c、TG、Fg、UA是糖尿病肾病的危险因素(优势比=1.008～1.910,P＜0.01～＜0.001).结论:糖尿病病程、血糖、血脂、血尿酸和纤维蛋白原是糖尿病肾病的危险因素；尿微量白蛋白/尿肌酐比值升高反映糖尿病人病情的进展,测定它有助于糖尿病的防治.
目的:探討影響糖尿病腎病的相關危險因素.方法:入選明確診斷2型糖尿病患者238例,根據尿微量白蛋白/尿肌酐的比值(UACR)分為糖尿病無腎病組(糖尿病1組,90例),早期糖尿病腎病組(糖尿病2組,73例),臨床糖尿病腎病組(糖尿病3組,75例),收集所有患者的臨床資料,併檢測餐前及餐後2h血糖(FBG、2hPB),血脂、尿痠(UA)、纖維蛋白原(Fg)、糖化血紅蛋白(HbA1c)等生化指標,併分析其與糖尿病腎病的相關性.結果:糖尿病1組、糖尿病2組、糖尿病3組的糖尿病病程[(7.25±6.29)年比(10.25±7.67)年比(13.53±7.82)年]、FBG[(8.46±2.52) mmol/L比(9.52±3.38) mmol/L比(10.82±3.30) mmol/L]、2hPB(18.40±5.64) mmol/L比(20.27±5.94) mmol/L比(22.59±6.14) mmol/L]、HbA1c[(7.96±1.65)％比(8.60±1.76)％比(9.55±2.09)％]、甘油三酯[(1.72±0.86) mmol/L比(2.34±1.87) mmol/L比(3.16±1.85) mmol/L]、Fg[(3.49±0.93) g/L比(3.88±1.21) g/L比(4.99±2.10) g/L]、UA [(295.42±52.34)μmol/L比(324.18±96.29) μmol/L比(351.23±56.88)μmol/L]水平逐漸顯著升高(P＜0.05～＜0.01). Logistic逐步迴歸分析顯示,糖尿病病程、HbA1c、TG、Fg、UA是糖尿病腎病的危險因素(優勢比=1.008～1.910,P＜0.01～＜0.001).結論:糖尿病病程、血糖、血脂、血尿痠和纖維蛋白原是糖尿病腎病的危險因素；尿微量白蛋白/尿肌酐比值升高反映糖尿病人病情的進展,測定它有助于糖尿病的防治.
목적:탐토영향당뇨병신병적상관위험인소.방법:입선명학진단2형당뇨병환자238례,근거뇨미량백단백/뇨기항적비치(UACR)분위당뇨병무신병조(당뇨병1조,90례),조기당뇨병신병조(당뇨병2조,73례),림상당뇨병신병조(당뇨병3조,75례),수집소유환자적림상자료,병검측찬전급찬후2h혈당(FBG、2hPB),혈지、뇨산(UA)、섬유단백원(Fg)、당화혈홍단백(HbA1c)등생화지표,병분석기여당뇨병신병적상관성.결과:당뇨병1조、당뇨병2조、당뇨병3조적당뇨병병정[(7.25±6.29)년비(10.25±7.67)년비(13.53±7.82)년]、FBG[(8.46±2.52) mmol/L비(9.52±3.38) mmol/L비(10.82±3.30) mmol/L]、2hPB(18.40±5.64) mmol/L비(20.27±5.94) mmol/L비(22.59±6.14) mmol/L]、HbA1c[(7.96±1.65)％비(8.60±1.76)％비(9.55±2.09)％]、감유삼지[(1.72±0.86) mmol/L비(2.34±1.87) mmol/L비(3.16±1.85) mmol/L]、Fg[(3.49±0.93) g/L비(3.88±1.21) g/L비(4.99±2.10) g/L]、UA [(295.42±52.34)μmol/L비(324.18±96.29) μmol/L비(351.23±56.88)μmol/L]수평축점현저승고(P＜0.05～＜0.01). Logistic축보회귀분석현시,당뇨병병정、HbA1c、TG、Fg、UA시당뇨병신병적위험인소(우세비=1.008～1.910,P＜0.01～＜0.001).결론:당뇨병병정、혈당、혈지、혈뇨산화섬유단백원시당뇨병신병적위험인소；뇨미량백단백/뇨기항비치승고반영당뇨병인병정적진전,측정타유조우당뇨병적방치.
Objective:To study relative risk factors for diabetic nephropathy (DN).Methods:A total of 238 patients diagnosed as type 2 diabetes mellitus (DM) were enrolled in the study.According to urine microalbuminuria to urine creatinine ratio (UACR),patients were divided into pure DM group (group DM1,n=90),early diabetic nephropathy group (group DM2,n=73) and clinical diabetic nephropathy group (group DM3,n=75).Clinic data of all patients were collected; Fasting blood glucose (FBG),2h postprandial blood glucose (2hPB),blood lipids,uric acid (UA),fibrinogen (Fg) and glycosylated haemoglobin (HbA1c) were measured in all patients,and their correlations with DN were analyzed.Results:Compared with group DM1,the course of disease in DM [ (7.25±6.29)years vs.(10.25±7.67) years vs.(13.53±7.82) years],levels of FBG [ (8.46±2.52) mmol/L vs.(9.52±3.38)mmol/Lvs.(10.82±3.30) mmol/L],2hPB[ (18.40±5.64) mmol/Lvs.(20.27±5.94) mmol/L vs.(22.59±6.14) mmol/L],HbA1c[ (7.96±1.65)％ vs.(8.60±1.76)％ vs.(9.55±2.09)％],triglyceride[TG,(1.72±0.86) mmol/Lvs.(2.34±1.87) mmol/Lvs.(3.16±1.85) mmol/L],Fg[(3.49±0.93) g/Lvs.(3.88±1.21) g/Lvs.(4.99±2.10) g/L] and UA[ (295.42±52.34) μmol/Lvs.(324.18±96.29) μmol/Lvs.(351.23±56.88)μmol/L] significantly increased in group DM2 and group DM3 in order ( P＜0.01 ～ ＜0.001).Logistic gradual regression analysis indicated that course of DM,HbA1c,TG,Fg and UA were risk factors for DN (OR=1.008～1.910,P＜0.01～＜0.001).Conclusion:The course of DM,blood glucose,blood lipid,uric acid and fibrinogen are risk factors for diabetic nephropathy; increased UACR reflects progress of patients' condition in DM patients,its detection is used for diabetic prognosis and treatment.
