CAJ | 학술논문

目的探讨人N-myc下游调节基因(NDRG1)在前列腺癌组织中的表达及其与分化程度和转移的关系.方法用免疫组化LSAB法检测86例不同Gleason级别的前列腺癌和30例良性前列腺增生组织中NDRG1的表达情况.结果 NDRG1在前列腺癌和良性前列腺增生组织中均呈高表达,阳性率分别为73.3%和70.0%,两者差异无统计学意义(P＞0.05);前列腺癌Gleason分级从2～4分→5～7分→8～10分,NDRG1的表达逐渐下降,差异有统计学意义(P＜0.05);NDRG1的阳性表达率在有淋巴结或骨转移的前列腺癌组织低于无淋巴结或骨转移的前列腺癌组织,两者呈负相关;NDRG1的表达与患者的年龄无关(P＞0.05).结论 NDRG1参与了前列腺癌的发生发展,并与前列腺癌的分化程度相关,有望成为一个早期预测肿瘤转移及预后的有用标志物.
목적 탐토인N-myc하유조절기인(NDRG1)재전렬선암조직중적표체급기여분화정도화전이적관계.방법 용면역조화LSAB법검측86례불동Gleason급별적전렬선암화30례량성전렬선증생조직중NDRG1적표체정황.결과 NDRG1재전렬선암화량성전렬선증생조직중균정고표체,양성솔분별위73.3%화70.0%,량자차이무통계학의의(P＞0.05);전렬선암Gleason분급종2～4분→5～7분→8～10분,NDRG1적표체축점하강,차이유통계학의의(P＜0.05);NDRG1적양성표체솔재유림파결혹골전이적전렬선암조직저우무림파결혹골전이적전렬선암조직,량자정부상관;NDRG1적표체여환자적년령무관(P＞0.05).결론 NDRG1삼여료전렬선암적발생발전,병여전렬선암적분화정도상관,유망성위일개조기예측종류전이급예후적유용표지물.
Objective To investigate the expression of NDRG1 and its relationship to differentiation level and metastasis in prostate cancer. Methods The expression NDRG1 was examined by immunohistochemistry LSAB method in 86 samples of prostate cancer and benigh prostate hyperplasia. Results The NDRG1 was shown to be highly expressed in 30(73.3%)of prostate cancer and 70.0%of benign prostate hyperplasia.There were no evident difference between prostate cancer and prestate hyperplasia(P＞0.05).The expression of NDRG1 was gradually reduction with the Gleason score from 2-4 to 5-7 to 8-10 in prostate cancer, which was statistical significance(P＜0.05).The expression of NDRG1 in lymph node or bone metastasis was significantly lower than that in no metastasis of prostate cancer. There was a negative correlation between the expression of NDRG1 and lymph node or bone metastasis. The age had no correlation with the expression of NDRG1(P＞0.05).Conclusion NDRG1 is involved in the genesis and development of prostate cancer, which may be related to the differentiation level of prostate cancer and serve as a useful marker for early diagnosis of cancer and metastasis.