CAJ | 학술논문

目的探讨关节镜下关节清理术并腔内注射川芎嗪对膝关节骨性关节炎的临床疗效.方法将60例膝关节骨性关节炎患者按随机数字表法分成治疗组和对照组,每组各30例.治疗组行关节镜下关节清理术并腔内注射川芎嗪;对照组行关节镜下关节清理术并腔内注射透明质酸钠.采用日本整形协会(JOA)制定的评定标准,于术后1周、3个月、6个月、12个月进行疗效评定;并检测术前、术后1周、4周、3个月关节液中一氧化氮(NO)含量.结果两组患者术后1周疗效比较差异无统计学意义(P>0.05),术后3、6、12个月治疗组优良率明显高于对照组(P<0.01).术前治疗组和对照组关节液中NO含量相近,分别为(90.32±22.24)μmol/L和(90.31 4±22.20)μmol/L,差异无统计学意义(P>0.05).至术后3个月,治疗组关节液中NO含量[(85.63 4±30.63)μmol/L]较术前下降显著(P<0.05),且明显低于对照组[(89.66±20.63)μmol/L](P<0.05);而对照组虽较术前降低,但差异无统计学意义(P>0.05).结论关节镜下关节清理术并腔内注射川芎嗪能有效控制软骨和滑膜的炎性反应,疗效持久稳定,是治疗膝关节骨性关节炎的有效方法.
목적 탐토관절경하관절청리술병강내주사천궁진대슬관절골성관절염적림상료효.방법 장60례슬관절골성관절염환자안수궤수자표법분성치료조화대조조,매조각30례.치료조행관절경하관절청리술병강내주사천궁진;대조조행관절경하관절청리술병강내주사투명질산납.채용일본정형협회(JOA)제정적평정표준,우술후1주、3개월、6개월、12개월진행료효평정;병검측술전、술후1주、4주、3개월관절액중일양화담(NO)함량.결과 량조환자술후1주료효비교차이무통계학의의(P>0.05),술후3、6、12개월치료조우량솔명현고우대조조(P<0.01).술전치료조화대조조관절액중NO함량상근,분별위(90.32±22.24)μmol/L화(90.31 4±22.20)μmol/L,차이무통계학의의(P>0.05).지술후3개월,치료조관절액중NO함량[(85.63 4±30.63)μmol/L]교술전하강현저(P<0.05),차명현저우대조조[(89.66±20.63)μmol/L](P<0.05);이대조조수교술전강저,단차이무통계학의의(P>0.05).결론 관절경하관절청리술병강내주사천궁진능유효공제연골화활막적염성반응,료효지구은정,시치료슬관절골성관절염적유효방법.
Objective To study the clinical therapeutic effect of arthroscopic debridement cooperated with injecting chuanxiongqin in treating knee osteoarthritis. Methods Sixty cases of knee osteoarthritis were randomly divided into 2 groups: treating group and control group, 30 cases in each group. The treating group were treated by arthroscopic debridement cooperated with injecting chuanxiongqin;the control group were given hyaluronate-Na after received arthroscopic debridement. The operation evaluation criteria of JOA was taken to value the therapeutic effect at 1 week, 3 months, 6 months and 12 months postoperation. At the same time, nitric oxide (NO) content in joint fluid were measured at preoperation, 1 week, 4 weeks, 3 months postoperation. Results At 1 week postoperation, there were no statistically significant differenced > 0.05) between the two groups,at 3, 6 and 12 months postoperation, the therapeutic effect of the treating group were much better than those of the control group (P < 0.01);NO content in joint fluid of preoperative treatment group [(90.32 ± 22.24) μmol/L]and control group [(90.31 ±22.20) μ mol/L]was similar, there was no significant difference (P >0.05). At 3 months postoperation, NO content in joint fluid of the treating group [(85.63 ± 30.63) μ mol/L]decreased significantly compared with preoperative (P < 0.05 ) , and the content was much lower than that of the control group [(89.66 ± 20.63 ) μ mol/L], there was significant difference between the two groups (P < 0.05). Although NO content in joint fluid of the control group was decreased, but the difference was not statistically significant (P >0.05). Conclusions Arthroscopic debridement with injecting chuanxiongqin in treating knee osteoarthritis can control inflammatory reaction of cartilage and synovia]in effect, improve the therapeutic effect. Therefore, it should be avalid method in treating knee osteoarthritis.