CAJ | 학술논문

目的探讨COX-2,iNOS,VEGF在大肠癌组织中的表达及其临床意义.方法采用免疫组化方法检测58例大肠癌组织中COX-2,iNOS,VEGF的表达,并分析其临床意义.结果 58例大肠癌组织中COX-2,iNOS,VEGF的阳性表达率分别为79.31%(46/58)、84.48%(49/58)和79.31%(46/58),显著高于正常大肠组织(P<0.01),与患者年龄、有无淋巴结转移、肿瘤体积及组织学类型差异无统计学意义(P>0.05),COX-2与VEGF的表达存在一定相关性(P<0.05),COX-2与iNOS的表达也存在一定相关性(P<0.05).结论大肠癌组织COX-2、iNOS的表达与肿瘤血管生成密切相关,二者可能与VEGF协同促进肿瘤血管生成,是判断肿瘤恶性程度及预后的的重要生物学指标.
목적 탐토COX-2,iNOS,VEGF재대장암조직중적표체급기림상의의.방법 채용면역조화방법검측58례대장암조직중COX-2,iNOS,VEGF적표체,병분석기림상의의.결과 58례대장암조직중COX-2,iNOS,VEGF적양성표체솔분별위79.31%(46/58)、84.48%(49/58)화79.31%(46/58),현저고우정상대장조직(P<0.01),여환자년령、유무림파결전이、종류체적급조직학류형차이무통계학의의(P>0.05),COX-2여VEGF적표체존재일정상관성(P<0.05),COX-2여iNOS적표체야존재일정상관성(P<0.05).결론 대장암조직COX-2、iNOS적표체여종류혈관생성밀절상관,이자가능여VEGF협동촉진종류혈관생성,시판단종류악성정도급예후적적중요생물학지표.
Objective To investigate expression of inducible nitric oxide synthase, cyclooxygenase-2and Vascular endothelial growth factor in human colorectal carcinoma and their clinical significances. Methods The expressions of COX-2, iNOS, VEGF in 58 casees of colorectal carcinoma tissue were assessed by immuno-histochemistry, and there relation to there clinical significance were statistically analyzed. Results Positive ex-pression rates of COX-2, iNOS, VEGF in 58 casees of colorectal carcinoma tissue were79.31% (46/58)、 84.48% (49/58),79.31% (46/58), which were significantly higher than that in colorectal tissues, the expres-sions of COX-2,iNOS, VEGF donnot relate to age,lymph node status and the structural type of eolorectal carci-noma(P>0.05). The expression of COX-2was correlated with VEGF and iNOS. (P<0.05). Conclusion COX-2,iNOS may promote angiogenesis through the way of VEGF,they may be important biological markers in evaluateing the malignant degree and prognosis.