CAJ | 학술논문

121例代谢综合征(MS)患者和120名对照者入选本研究以探讨血清脂肪因子与MS的关系.对照组、非腹型肥胖MS组及腹型肥胖MS组的血清抵抗素和脂肪细胞型脂肪酸结合蛋白(A-FABP)依次增高,而脂联素水平依次降低(均P<0.05).MS组抵抗素与体重指数(BMI)、腰围、收缩压、空腹血糖和A-FABP呈正相关(P<0.05或P<0.01);脂联素与高密度脂蛋白胆固醇呈正相关,而与BMI、腰围、空腹胰岛素、甘油三酯、稳态模型评估的胰岛素抵抗指数(HOMA-IR)呈负相关.
121례대사종합정(MS)환자화120명대조자입선본연구이탐토혈청지방인자여MS적관계.대조조、비복형비반MS조급복형비반MS조적혈청저항소화지방세포형지방산결합단백(A-FABP)의차증고,이지련소수평의차강저(균P<0.05).MS조저항소여체중지수(BMI)、요위、수축압、공복혈당화A-FABP정정상관(P<0.05혹P<0.01);지련소여고밀도지단백담고순정정상관,이여BMI、요위、공복이도소、감유삼지、은태모형평고적이도소저항지수(HOMA-IR)정부상관.
A total of 121 patients with metabolic syndrome (MS) and 120 normal subjects were recruited for exploring the association of serum adipokines with MS. The levels of resistin and adipocyte fatty acid-binding protein (A-FABP) increased, while adiponectin decreased gradually ( all P<0.05 ) in normal control group, MS without abdominal obesity group, and MS with abdominal obesity group. In MS group, resistin was positively correlated with body mass index ( BMI), waist circumference, systolic blood pressure, fasting plasma glucose, and A-FABP ( P<0.05 or P<0.01 ). Adiponectin was positively correlated with high-density lipoprotein-cholesterol and negatively correlated with BMI, waist circumference, fasting insulin, triglyceride, and homeostasis assessment of insulin resistant index.