米格列奈钙对初诊2型糖尿病患者血浆成纤维细胞生长因子21水平的影响
미격렬내개대초진2형당뇨병환자혈장성섬유세포생장인자21수평적영향
Effect of mitiglinide calcium on fasting plasma fibroblast growth factor-21 level in patients with newly diagnosed type 2 diabetes mellitus
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2012年 2期 143-145 ,共3页

    范莹莹%杨刚毅%李伶%李志勇%廖涌%程春瑞%汤世国%李生兵%李娜%王毅

    범형형%양강의%리령%리지용%료용%정춘서%탕세국%리생병%리나%왕의

    米格列奈钙%糖尿病,2型%成纤维细胞生长因子21 米格列奈鈣%糖尿病,2型%成纖維細胞生長因子21
    미격렬내개%당뇨병,2형%성섬유세포생장인자21
    Mitiglinide calcium%Diabetes mellitus,type 2%Fibroblast growth factor-21
    82例初诊2型糖尿病,给予口服米格列奈钙片16周,测定治疗前后血浆成纤维细胞生长因子21(FGF-21)水平,分析血浆FGF-21水平与体重指数、血脂、空腹血糖、血浆胰岛素、胰岛素抵抗指数和胰岛β细胞分泌指数等水平的关系.米格列奈钙能有效降低2型糖尿病患者血浆FGF-21水平,血浆FGF-21水平变化可能与2型糖尿病的发生发展有关.
    82례초진2형당뇨병,급여구복미격렬내개편16주,측정치료전후혈장성섬유세포생장인자21(FGF-21)수평,분석혈장FGF-21수평여체중지수、혈지、공복혈당、혈장이도소、이도소저항지수화이도β세포분비지수등수평적관계.미격렬내개능유효강저2형당뇨병환자혈장FGF-21수평,혈장FGF-21수평변화가능여2형당뇨병적발생발전유관.
    Eighty-two newly-diagnosed type 2 diabetic patients with poor glycemic control were treated by mitiglinide calcium for 16 weeks.Plasma fibroblast growth factor-21 ( FGF-21 ) level were evaluated.The relationship of plasma FGF-21 levels with body mass index,body fat,waist-to-hip ratio,lipid,blood glucose,HbA1c,and free fatty-acid were analyzed.Plasma FGF-21 was decreased significantly by treatment with mitiglinide calcium in type 2 diabetic patients,and it may play a role in the pathogenesis of type 2 diabetes mellitus.
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