CAJ | 학술논문

目的探讨初发和复发尖锐湿疣(CA)患者皮损中TLR4、TLR9和DC-SIGN的表达及意义.方法采用免疫组化SP法检测30例初发CA皮损、30例复发CA皮损和20例正常人皮肤(包皮)中TLR4、TLR9和DC-SIGN的表达及分布.结果初发CA皮损和复发CA皮损中TLR4、TLR9和DC-SIGN的表达水平均显著高于正常包皮组织(P<0.001),且集中分布于基底层和棘层细胞.TLR4、TLR9和DC-SIGN三者在初发CA皮损和复发CA皮损中的表达差异均无统计学意义(三者均P>0.05).TLR4、TLR9与DC-SIGN的表达均呈正相关性关系.结论 TLR4、TLR9和DC-SIGN的表达增强可能在CA的发病和复发过程中起到一定作用.
목적탐토초발화복발첨예습우(CA)환자피손중TLR4、TLR9화DC-SIGN적표체급의의.방법채용면역조화SP법검측30례초발CA피손、30례복발CA피손화20례정상인피부(포피)중TLR4、TLR9화DC-SIGN적표체급분포.결과초발CA피손화복발CA피손중TLR4、TLR9화DC-SIGN적표체수평균현저고우정상포피조직(P<0.001),차집중분포우기저층화극층세포.TLR4、TLR9화DC-SIGN삼자재초발CA피손화복발CA피손중적표체차이균무통계학의의(삼자균P>0.05).TLR4、TLR9여DC-SIGN적표체균정정상관성관계.결론 TLR4、TLR9화DC-SIGN적표체증강가능재CA적발병화복발과정중기도일정작용.
Objective To investigate the expression and significance of TLR4, TLR9 and DC-SIGN in primary and recurrent condyloma acuminatum (CA) lesions. Methods An immunohistochemical method using streptavidin-peroxidase (SP) was performed to detect the expressions and distribution of TLR4, TLR9 and DC-SIGN in tissue specimens obtained from the recurrent CA lesions of 30 patients, primary CA lesions of 30 patients, and from the foreskin of 20 normal human controls. Results The expression levels of TLR4, TLR9 and DC-SIGN in primary and recurrent CA lesions were significantly higher than those in normal control tissue (all P < 0.001), and the cells expressing TLR4, TLR9 or DC-SIGN were mainly located in the basal and spinous layer in CA lesions. There was no significant difference in the expressions of TLR4, TLR9 or DC-SIGN between primary and recurrent CA lesions (all P> 0.05). A positive correlation was found between the expression of TLR4, TLR9 and DC-SIGN in CA lesions. Conclusion The overexpression of TLR4, TLR9 and DC-SIGN probably plays an important role in the occurrence and recurrence of CA.