药学学报
藥學學報
약학학보
ACTA PHARMACEUTICA SINICA
2001年
1期
38-41
,共4页
刘戎%丁立生%陈能煜%王明奎
劉戎%丁立生%陳能煜%王明奎
류융%정립생%진능욱%왕명규
毛萼梅%三萜%2α,3β-二羟基乌苏-12,19-二烯-23,28-二酸
毛萼梅%三萜%2α,3β-二羥基烏囌-12,19-二烯-23,28-二痠
모악매%삼첩%2α,3β-이간기오소-12,19-이희-23,28-이산
目的 研究毛萼梅根部的化学成分。方法 将MeOH提取物分散于水中,经EtOAc萃取后用柱色谱分离纯化,通过波谱方法鉴定化合物。结果 鉴定了7个化合物:2α,3β-二羟基乌苏-12,19-二烯-23,28-二酸(I),2α,3β,23-三羟基乌苏-12,18-二烯-28-酸(IIa),2α,3β,23-三羟基乌苏-12,19-二烯-28-酸(IIb),2α,3α-二羟基乌苏-12,18-二烯-28-酸(IIIa),2α,3α-二羟基乌苏-12,19-二烯-28-酸(IIIb),及化合物IIIa，IIIb的C-2,C-3位缩酮IVa和IVb。结论 I是1个新三萜酸。
目的 研究毛萼梅根部的化學成分。方法 將MeOH提取物分散于水中,經EtOAc萃取後用柱色譜分離純化,通過波譜方法鑒定化閤物。結果 鑒定瞭7箇化閤物:2α,3β-二羥基烏囌-12,19-二烯-23,28-二痠(I),2α,3β,23-三羥基烏囌-12,18-二烯-28-痠(IIa),2α,3β,23-三羥基烏囌-12,19-二烯-28-痠(IIb),2α,3α-二羥基烏囌-12,18-二烯-28-痠(IIIa),2α,3α-二羥基烏囌-12,19-二烯-28-痠(IIIb),及化閤物IIIa，IIIb的C-2,C-3位縮酮IVa和IVb。結論 I是1箇新三萜痠。
목적 연구모악매근부적화학성분。방법 장MeOH제취물분산우수중,경EtOAc췌취후용주색보분리순화,통과파보방법감정화합물。결과 감정료7개화합물:2α,3β-이간기오소-12,19-이희-23,28-이산(I),2α,3β,23-삼간기오소-12,18-이희-28-산(IIa),2α,3β,23-삼간기오소-12,19-이희-28-산(IIb),2α,3α-이간기오소-12,18-이희-28-산(IIIa),2α,3α-이간기오소-12,19-이희-28-산(IIIb),급화합물IIIa，IIIb적C-2,C-3위축동IVa화IVb。결론 I시1개신삼첩산。
AIM To investigate the chemical constituents of Rubus chroosepalus Focke. METHODS The methanol extracts were suspended in H2O and then extracted with EtOAc. Column chromatography was used for separation and purification, while spectral analysis was used for identification. RESULTS Seven compounds were isolated and identified as 2α,3β-dihydroxy-urs-12,19-dien-23,28-oic acid (I), 2α,3β,23-trihydroxy-urs-12,18-dien-28-oic acid (IIa), 2α,3β,23-trihydroxy-urs-12,19-dien-28-oic acid (IIb), 2α,3α-dihydroxy-urs-12,18-dien-28-oic acid (IIIa), 2α,3α-dihydroxy-urs-12,19-dien-28-oic acid (IIIb), and the acetonide of IIIa and IIIb (IVa and IVb). CONCLUSION I was found to be a new pentacyclic triterpenoid acid.
