CAJ | 학술논문

目的了解葡萄糖毒性对胰岛β细胞分泌功能的影响. 方法观察118例2型糖尿病(T2DM)患者在不同血糖状态下,胰岛β细胞分泌对口服葡萄糖耐量试验(OGTT)和胰高血糖素刺激试验(GST)的反应能力. 结果胰岛β细胞的分泌功能在OGTT随空腹血糖的升高而下降(P<0.01);在GST随血糖升高而增强,达9 mmol/L以上时维持在高水平.OGTT胰岛素释放倍数与胰岛素抵抗指数(HOMA-IR)呈负相关(P<0.01),GST胰岛素释放倍数与胰岛β细胞功能指数(HOMA-β)呈正相关(P<0.01). 结论葡萄糖毒性干扰胰岛β细胞功能的判断,血糖过高抑制OGTT时的胰岛素释放,GST受此影响小,能较客观反映胰岛β细胞功能状态.
목적료해포도당독성대이도β세포분비공능적영향. 방법관찰118례2형당뇨병(T2DM)환자재불동혈당상태하,이도β세포분비대구복포도당내량시험(OGTT)화이고혈당소자격시험(GST)적반응능력. 결과이도β세포적분비공능재OGTT수공복혈당적승고이하강(P<0.01);재GST수혈당승고이증강,체9 mmol/L이상시유지재고수평.OGTT이도소석방배수여이도소저항지수(HOMA-IR)정부상관(P<0.01),GST이도소석방배수여이도β세포공능지수(HOMA-β)정정상관(P<0.01). 결론포도당독성간우이도β세포공능적판단,혈당과고억제OGTT시적이도소석방,GST수차영향소,능교객관반영이도β세포공능상태.
Objective To evaluate the effect of chronic hyper glycaemia on the pancreatic β-cell response in diabetic patients. Me thods We investigated the effect of various blood glucose levels on the β-cell response to stimulation with a standard oral glucose or intravenous gl ucagon in 118 patients with type 2 diabetes. Results The rele ases of C-peptide and insulin were decreased with increased level of fasting blood glucose (P<0.01)after oral glucose stimulation, and were increased with decreased levels of fasting blood glucose after glucagon stimulation wh ile C-peptide and insulin release keeping higher when fasting blood glucose lev el was above 9 mmol/L. The release of insulin showed an inverse association to HOMA-IR (P<0.01)after oral glucose stimulation and it showed a positive association with HOMA-β(P<0.01)after glucagon stimulation. C onclusions The evaluation of function of β-cell secretion is confused by glucose toxicity because severe hyperglycaemia significantly reduces C-pep tide and insulin release after oral glucose stimulation, but this is not the cas e after glucagon stimulation in type 2 diabetic patients.