CAJ | 학술논문

用X射线衍射法对那格列奈的多晶型结构进行了测定,并进行了动物模拟降血糖试验.结果表明:那格列奈具有B晶型、H晶型和S晶型三种结构.H晶型为三斜晶系,晶胞参数a=1.769 9(7)nm,b=2.719 1(8)nm,c=1.267 0(6)nm,α=61.75(3)°,β=73.11(6)°,γ=66.77(7)°,V=4.895 nm3,Z=10.S晶型为正交晶系,晶胞参数a=2.317 8(6)nm,b=2.533 2(5)nm,c=0.653 1(2)nm,α=β=γ=90°,V=3.835 nm3,Z=8.小白鼠模拟降糖试验表明:与目前上市的H晶型相同,S晶型也具有很好的降血糖作用,特别是在用药40min时,效果更显著.
용X사선연사법대나격렬내적다정형결구진행료측정,병진행료동물모의강혈당시험.결과표명:나격렬내구유B정형、H정형화S정형삼충결구.H정형위삼사정계,정포삼수a=1.769 9(7)nm,b=2.719 1(8)nm,c=1.267 0(6)nm,α=61.75(3)°,β=73.11(6)°,γ=66.77(7)°,V=4.895 nm3,Z=10.S정형위정교정계,정포삼수a=2.317 8(6)nm,b=2.533 2(5)nm,c=0.653 1(2)nm,α=β=γ=90°,V=3.835 nm3,Z=8.소백서모의강당시험표명:여목전상시적H정형상동,S정형야구유흔호적강혈당작용,특별시재용약40min시,효과경현저.
The nateglinide polymorphism structure and the effect on reducing the level of blood glucose are determined.The results indicate that nateglinide has three crystal forms, B-form, H-form and S-form. H-form belongs to the triclinic crystal system with the lattice constant a= 1. 769 9 (7) nm, b = 2.719 1 ( 8 ) nm, c = 1. 267 0 (6) nm, α = 61.75 (3) °,β = 73.11 ( 6 ) °, γ = 66.77 ( 7 ) °, V = 4. 895 nm3 , Z = 10. S-form belongs to the orthorhombic crystal system with the lattice constant a = 2.317 8 (6) nm, b = 2. 533 2 ( 5 ) nm, c = 0. 653 1 ( 2 ) nm, α =β= γ = 90°, V= 3. 835 nm3, Z =8. S-form Nateglinide can significantly reduce the level of blood glucose of administration in high glucohemia mice like the H-form. Especially after 40 min the efficacy is much better.