CAJ | 학술논문

目的:探讨乳腺癌术中诊断前哨淋巴结(sentinel lymph node,SLN)转移的最佳病理学方法. 方法: 收集204例乳腺癌患者,并进行淋巴结定位,前哨淋巴结活检、术中病理诊断.102例(A法)患者的前哨淋巴结均二等分后再进行连续切片,另外102例(B法)患者的前哨淋巴结先切成1mm-1.5mm厚的薄片,置于冷冻托头上,用水溶胶包埋;再从各个组织切面进行印片细胞检查,然后进行连续切片检查.以前哨淋巴结转移的术后诊断作为金标准. 结果: A组28(27%)例、B组42(40%)例检出前哨淋巴结转移(P=0.05).前哨淋巴结转移灶平均大小:A组5.5mm、B组3.3mm(P<0.05). 结论: B法能检出更多、更小的转移灶,并且需时少,花费人力少.而A法许多微小转移性不能检出.
목적:탐토유선암술중진단전초림파결(sentinel lymph node,SLN)전이적최가병이학방법. 방법: 수집204례유선암환자,병진행림파결정위,전초림파결활검、술중병리진단.102례(A법)환자적전초림파결균이등분후재진행련속절편,령외102례(B법)환자적전초림파결선절성1mm-1.5mm후적박편,치우냉동탁두상,용수용효포매;재종각개조직절면진행인편세포검사,연후진행련속절편검사.이전초림파결전이적술후진단작위금표준. 결과: A조28(27%)례、B조42(40%)례검출전초림파결전이(P=0.05).전초림파결전이조평균대소:A조5.5mm、B조3.3mm(P<0.05). 결론: B법능검출경다、경소적전이조,병차수시소,화비인력소.이A법허다미소전이성불능검출.
Objective:To explore the best intraoperative pathologic method of diagnosing sentinel lymph node(SLN) metastasis in patients with breast cancer. Methods: Total of 204 samples of patients with breast cancer were collected.Then Lymph node location,SLN biopsy and intraoperative pathologic diagnosis were conducted.In group A,all 102 SLN samples were further halved,and cut into serial sections(method A).In group B,SLN samples were cut into slices with thickness of 1 to 1.5 mm,put on the apparatus and embedded in hydrosol,then cut into serial sections after imprint cytoscopy(method B).The results of postoperative diagnosis were set as Gold Standard. Results: Twenty eighty samples (27%) of Group A and 42 samples(40%) of Group B were detected to have SLN metastases(P=0.05),and the average size of the SLN metastases was 5.5 mm for Group A and 3.3 mm for Group B,respectively(P< 0.05). Conclusion: Method B is more efficient than method A in finding more and smaller metastasis,and economical in time and manpower.Many minute metastases can not be detected in method A.