CAJ | 학술논문

AIM: To explore the role of Helicobacter pylori ( H pylori) infection on the risk of digestive tract cancers.METHODS: In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection.Two hospital- and one community-based control groups were used for the comparisons.H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG.RESULTS: Presence of H pylori infection was signifi- cantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups.Similar results were not found in cancers of the oral cavity and colon.CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.