CAJ | 학술논문

目的评价联合检测血清胃蛋白酶原Ⅰ(PG Ⅰ)和癌胚抗原(CEA)临床价值和可行性.方法回顾性分析402例胃溃疡患者的血清PG Ⅰ和CEA检测结果.结果 402例患者中有73例恶变,73例癌性溃疡患者中PG Ⅰ和CEA阳性表达分别为38和47例,两者皆表达阳性为22例.联合检测结果阳性63例,单独PG Ⅰ和CEA检测与联合检测差异有统计学意义(P值分别＜0.05和0.01).结论对癌性溃疡患者,与单独检测相比,PC Ⅰ和CEA联合检测提高了灵敏性,是临床上值得推广的一种方法.
목적 평개연합검측혈청위단백매원Ⅰ(PG Ⅰ)화암배항원(CEA)림상개치화가행성.방법 회고성분석402례위궤양환자적혈청PG Ⅰ화CEA검측결과.결과 402례환자중유73례악변,73례암성궤양환자중PG Ⅰ화CEA양성표체분별위38화47례,량자개표체양성위22례.연합검측결과양성63례,단독PG Ⅰ화CEA검측여연합검측차이유통계학의의(P치분별＜0.05화0.01).결론 대암성궤양환자,여단독검측상비,PC Ⅰ화CEA연합검측제고료령민성,시림상상치득추엄적일충방법.
Objective The aim of this study was to evaluate the clinical value and the possibilities of measuring the serum levels of pepsinogen I (PG I ) and careineembryonic antigen (CEA) in 402 patients with gastric ulcer.Methods The patients with gastric ulcer were all confirmed by either operation or gastrofiberscope,and divided into two groups,benign and malignant gastric ulcer.After comparing the relationship between the patients'clinical appearance and the Radioimmunoaasay(RIA) results,(CEA and PG I ).Results There were 73 patients were onfirmed malignant gastric ulee in 402 patients.The positive rate of PG was 52.05% (38/73).The positive rate of CEA was 64.38% (47/73).Both were 30.14% (22/73).Then there were 63(63/73) patients who was positive in the combined determination.Solo determination's positive rate of CEA and PG were significantly different from the combined determination.(P＜0.05 and 0.01) Conclusions Feasibility and the necessity of combined determination were evaluated.Compared with solo determination,for patients with malignant gastric ulcer,it was more sensitive to determine and analysis the serum levels of PG I and CEA sYnthetically.So it is recommended to popularize the combined determination of serum PG I and CEA in clinical distinctive diagnosis of benign and malignant gastric ulcer.