CAJ | 학술논문

目的应用超声心动图评价克山病患者自我治疗的疗效,观察心脏形态及功能变化.方法观察经自我治疗的31例克山病患者治疗前、治疗后3个月及6个月时的左房内径(LAd)、左室舒张末期内径(LVEDd)、室间隔舒张末期厚度(IVSTd)、左室后壁舒张末期厚度(LVPWTd)、左室质量(LVM)、左室质量指数(LVMI)、相对室壁厚度(RWT)、左室射血分数(LVEF)、二尖瓣血流E/A值大小及变化情况.结果克山病患者经自我治疗3个月后LAd、IVSTd、LVEDd、LVPWTd、LVM、LVMI及RWT测值均较治疗前减小,治疗6个月后进一步减小,差异有统计学意义(P＜0.05).LVEF值与治疗前相比略有增大,但差异无统计学意义(P＞0.05).结论克山病患者经自我治疗后左室肥厚及左室重构受到限制,并发生了逆转,心功能得到了相应改善.超声心动图为克山病患者自我治疗疗效的评价提供了有效的方法,并为临床治疗提供指导.
목적 응용초성심동도평개극산병환자자아치료적료효,관찰심장형태급공능변화.방법 관찰경자아치료적31례극산병환자치료전、치료후3개월급6개월시적좌방내경(LAd)、좌실서장말기내경(LVEDd)、실간격서장말기후도(IVSTd)、좌실후벽서장말기후도(LVPWTd)、좌실질량(LVM)、좌실질량지수(LVMI)、상대실벽후도(RWT)、좌실사혈분수(LVEF)、이첨판혈류E/A치대소급변화정황.결과 극산병환자경자아치료3개월후LAd、IVSTd、LVEDd、LVPWTd、LVM、LVMI급RWT측치균교치료전감소,치료6개월후진일보감소,차이유통계학의의(P＜0.05).LVEF치여치료전상비략유증대,단차이무통계학의의(P＞0.05).결론 극산병환자경자아치료후좌실비후급좌실중구수도한제,병발생료역전,심공능득도료상응개선.초성심동도위극산병환자자아치료료효적평개제공료유효적방법,병위림상치료제공지도.
Objective To evaluate the effect of self-treatment and observe the change of heart morphology and function in patients with Keshan disease by echocardiography.Methods The left atrium diameter(LAd),left ventricular end-diastolic diameter(LVEDd),the thickness of interventricular septum in end diastolic(IVSTd),the thickness of left ventricular posterior wall in end-diastolic(LVPWTd),the left ventricular mass(LVM),the left ventricular mass index(LVMI),the relative wall thickness(RWT),the left ventricular ejection fraction(LVEF)and the mitral valve flow E/A ratio(E/A)were measured before the self treatment by echocardiography,and also measured on the 3rd month and 6th month after self-treatment with the same method,and observed the change of the parameters above.Results The LAd,LVEDd,IVSTd,LVPWTd,LVM,LVMI and RWT decreased on the 3rd month after self-treatment compared with prior self-treatment,and decreased on the 6th month further.There was significant difference between the prior self-treatment and post self-treatment(P＜0.05).The mitral valve flow E/A ratio and LVEF increased on the post self-treatment compared with the prior self-treatment slightly,but there was no statistical difference(P＞0.05).Conclusions Left ventricular hypertrophy and remodeling in patients with Keshan disease were prevented and reversed,and the cardiac function were improved after the self-treatment.Echocardiography can be used to evaluate the effect of self-treatment on patients with Keshan disease and can provide direction for clinical treatment.