CAJ | 학술논문

目的探讨肿瘤坏死因子TNFα-1031 T/C基因多态性与阿尔茨海默病(Alzheimer disease,AD)的关系.方法采用聚合酶链式反应-限制性片段长度多态性(CR-RFLP)技术检测66例AD患者(AD组)及119名正常人(正常对照组)的TNFα-1031 T/C基因多态性.结果 AD组TNFα-1031 T/T、T/C、C/C表型频率分别为:68.18、28.78、3.03,对照组分别为57.99、41.17、0.84;AD组TNFα-1031 T、TNFα-1031 C基因频率分别为:82.58、17.42,对照组分别为:78.57、21.43;AD组TNFα-1031各种基因型频率及T、C等位基因的分布与正常对照组比较没有显著性差异(P＞0.05).结论 TNFα-1031 T/C基因多态性与AD无明显相关性.
목적 탐토종류배사인자TNFα-1031 T/C기인다태성여아이자해묵병(Alzheimer disease,AD)적관계.방법 채용취합매련식반응-한제성편단장도다태성(CR-RFLP)기술검측66례AD환자(AD조)급119명정상인(정상대조조)적TNFα-1031 T/C기인다태성.결과 AD조TNFα-1031 T/T、T/C、C/C표형빈솔분별위:68.18、28.78、3.03,대조조분별위57.99、41.17、0.84;AD조TNFα-1031 T、TNFα-1031 C기인빈솔분별위:82.58、17.42,대조조분별위:78.57、21.43;AD조TNFα-1031각충기인형빈솔급T、C등위기인적분포여정상대조조비교몰유현저성차이(P＞0.05).결론 TNFα-1031 T/C기인다태성여AD무명현상관성.
Objective To explore the relationship of polymorphism of Tumor Necrosis Factor a- 1031 gene and Alzheimer disease. Method The genotypes of TNFa-1031 gene were determined by poly- merase chain reaction-based assay in 66 patients with Alzheimer disease and 119 healthy controls. Results The phenotype frequenceies of TNFa-1031 T/T, T/C, C/C in patients with AD is 68.18, 28.78, 3.03 respectively; the control groups is 57.99、 41.17、 0.84 respectively. The phenotype frequenceies of TNFa- 1031 T, TNFa-1031 C in patients with AD is 82.58、17.42 respectively. There were no significant differences in the phenotype frequenceies of TNFa-1031 between the patients and central groups ( P>0.05 ). Conclu- mion There is no significant relationship between the polymorphism of TNFa-1031 gene and AD.