中华现代护理杂志
中華現代護理雜誌
중화현대호리잡지
CHINESE JOURNAL OF MODERN NURSING
2010年
14期
1650-1651
,共2页
中心静脉导管%外周静脉留置针%奥沙利铂%神经毒性%肢体疼痛
中心靜脈導管%外週靜脈留置針%奧沙利鉑%神經毒性%肢體疼痛
중심정맥도관%외주정맥류치침%오사리박%신경독성%지체동통
Central venous catheter%Peripheral central-vein indwelling needle%Oxaliplatin%Neurotoxicity%Limb pain
目的 探讨经外周静脉置入的中心静脉导管(PICC)与外周静脉留置针输入奥沙利铂对患者造成神经毒性的差异.方法 将58例拟行奥沙利铂化疗方案的消化道恶性肿瘤患者分为PICC组(n=32)和外周组(n=29),PICC组经PICC输入奥沙利铂,外周组经外周静脉留置针输入奥沙利铂,对比观察2种给药途径引起周围神经毒性反应以及药物引起肢体疼痛情况.结果 PICC组出现3例神经毒性反应,均为一级,无一例出现肢体疼痛;外周组18例出现神经毒性反应,其中一级10例,二级8例,有11例出现输注侧肢体局部疼痛.PICC组神经毒性发生率明显低于外周组,差异有统计学意义(P＜0.01).结论 经PICC输入奥沙利铂,神经毒性反应轻,可避免引起肢体疼痛,有利于提高患者化疗依从性.
目的 探討經外週靜脈置入的中心靜脈導管(PICC)與外週靜脈留置針輸入奧沙利鉑對患者造成神經毒性的差異.方法 將58例擬行奧沙利鉑化療方案的消化道噁性腫瘤患者分為PICC組(n=32)和外週組(n=29),PICC組經PICC輸入奧沙利鉑,外週組經外週靜脈留置針輸入奧沙利鉑,對比觀察2種給藥途徑引起週圍神經毒性反應以及藥物引起肢體疼痛情況.結果 PICC組齣現3例神經毒性反應,均為一級,無一例齣現肢體疼痛;外週組18例齣現神經毒性反應,其中一級10例,二級8例,有11例齣現輸註側肢體跼部疼痛.PICC組神經毒性髮生率明顯低于外週組,差異有統計學意義(P＜0.01).結論 經PICC輸入奧沙利鉑,神經毒性反應輕,可避免引起肢體疼痛,有利于提高患者化療依從性.
목적 탐토경외주정맥치입적중심정맥도관(PICC)여외주정맥류치침수입오사리박대환자조성신경독성적차이.방법 장58례의행오사리박화료방안적소화도악성종류환자분위PICC조(n=32)화외주조(n=29),PICC조경PICC수입오사리박,외주조경외주정맥류치침수입오사리박,대비관찰2충급약도경인기주위신경독성반응이급약물인기지체동통정황.결과 PICC조출현3례신경독성반응,균위일급,무일례출현지체동통;외주조18례출현신경독성반응,기중일급10례,이급8례,유11례출현수주측지체국부동통.PICC조신경독성발생솔명현저우외주조,차이유통계학의의(P＜0.01).결론 경PICC수입오사리박,신경독성반응경,가피면인기지체동통,유리우제고환자화료의종성.
Objective To explore the the different effects of two different ways of infusion on patients with neurotoxicity caused by oxaliplatin chemotherapy: peripheral inserted central catheter (PICC) vs peripheral central-vein indwelling needle (PCVIN). Methods A total of 58 gastrointestinal malignancy cases reicived oxaliplatin were divided into PICC group ( n = 32) and PCVIN group ( n = 29 ), incidence of toxicity and physical pain were compared. Results There were 3 cases with neurotoxicity( all at level 1 ) amd there were no cases with physical pain in PICC group, while there were 18 cases with neurotoxicity (10 cases at level 1 and 8 cases at level 2) and there were 11 cases with limb pain. The difference between groups was statistically significant (P＜0.01). Conclusions Oxaliplatin infusion through PICC can reduce neurotoxic reaction,decrease physical pain and improve patients' compliance with chemotherapy.
