中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
4期
347-350
,共4页
脂联素%脂联素受体%信号途径%卵巢功能%多囊卵巢综合征
脂聯素%脂聯素受體%信號途徑%卵巢功能%多囊卵巢綜閤徵
지련소%지련소수체%신호도경%란소공능%다낭란소종합정
Adiponectin%Adiponectin receptor%Signal pathway%Ovary function%Polycystic ovary syndrome
证据提示脂联素在卵巢分泌类固醇激素和胎盘发育中发挥了重要的作用.其不仅直接影响晚期卵泡的合成,还影响胰岛素与促性腺激素释放激素作用从而影响初始卵泡形成.脂联素通过多种信号途径对卵巢功能和胎盘形成具有潜在性的作用,为代谢及生殖相关疾病的病因学研究和治疗提供新的思路.
證據提示脂聯素在卵巢分泌類固醇激素和胎盤髮育中髮揮瞭重要的作用.其不僅直接影響晚期卵泡的閤成,還影響胰島素與促性腺激素釋放激素作用從而影響初始卵泡形成.脂聯素通過多種信號途徑對卵巢功能和胎盤形成具有潛在性的作用,為代謝及生殖相關疾病的病因學研究和治療提供新的思路.
증거제시지련소재란소분비류고순격소화태반발육중발휘료중요적작용.기불부직접영향만기란포적합성,환영향이도소여촉성선격소석방격소작용종이영향초시란포형성.지련소통과다충신호도경대란소공능화태반형성구유잠재성적작용,위대사급생식상관질병적병인학연구화치료제공신적사로.
There is a strong support for a role played by adiponectin in the function of ovary and placenta.There is evidence of direct effects of adiponectin on the late stages of folliculogenesis,and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles.Adiponectin has demonstrated a potential effect on ovarian function as well as a possible effect on the formation of placenta,via multiple mechanisms,providing new strategies for the etiology investigation,prevention and treatment of reproductive and related metabolic diseases.