CAJ | 학술논문

目的通过对未经治疗的抑郁症首次发病(以下简称首发)患者进行弥散张最成像(DTI)检查,探讨抑郁症患者脑门质的完整性及其与病程和抑郁严重程度的相关性.方法对17名首发末服药抑郁症患者(以下简称患者组)和17名年龄、性别和文化程度相匹配的健康对照(以下简称对照组)进行全脑DTI扫描.以基于体素的分析比较两组受试者脑白质的分数各向异性(FA)的差异.提取差异有统计学意义的脑区的FA绝对值,将其与汉密尔顿抑郁量表(17项,HAMD)总分和患者病程进行相关分析.结果患者组的双侧额中回、左侧扣带回和颞下回白质的FA值显著低于对照组(P＜0.01,cluster＞100).右侧额中回的FA值与病程呈显著负相关(r=-0.732,P=0.001).未发现各脑区的FA值与HAMD总分存在相关.结论脑白质完整性异常可能是抑郁症的生物学特征之一,抑郁症病程对脑白质的完整性有明显影响.
목적 통과대미경치료적억욱증수차발병(이하간칭수발)환자진행미산장최성상(DTI)검사,탐토억욱증환자뇌문질적완정성급기여병정화억욱엄중정도적상관성.방법 대17명수발말복약억욱증환자(이하간칭환자조)화17명년령、성별화문화정도상필배적건강대조(이하간칭대조조)진행전뇌DTI소묘.이기우체소적분석비교량조수시자뇌백질적분수각향이성(FA)적차이.제취차이유통계학의의적뇌구적FA절대치,장기여한밀이돈억욱량표(17항,HAMD)총분화환자병정진행상관분석.결과 환자조적쌍측액중회、좌측구대회화섭하회백질적FA치현저저우대조조(P＜0.01,cluster＞100).우측액중회적FA치여병정정현저부상관(r=-0.732,P=0.001).미발현각뇌구적FA치여HAMD총분존재상관.결론뇌백질완정성이상가능시억욱증적생물학특정지일,억욱증병정대뇌백질적완정성유명현영향.
Objective To explore the white matter integrity via diffusion tensor imaging(DTI)in first-episode treatment-naive major depressive patients and their correlations with the course and severity of depression.Methods Seventeen first-episode treatment-naive young adult major depressive patients [Hamilton Rating Scale for Depression._( 17) (HAMD-_(17))＞17]and seventeen healthy subjects(HAMD-_(17)＜7)matched in gender.age and education underwent clinical assessment and DTI scan.Voxel-based analysis was used to examine the fractional anisotropy(FA)difference of whole brain white matter between the patients and healthy subjects.Clinical association of the average FA value of identified clusters with the course and severity of depression was examined by using bivariate correlation analysis.Results The patients with major depression exhibited significantly lower FA than healthy subjects in the white matter of bilateral middle frontal gyrus,left cingulate gyrus and left inferior temporal gyrus.The illness course,but not HAMD scores,was significantly negatively correlated to FA of the right middle frontal gyrus(r=-0.732,P=0.001).Conclusion Brain white matter integrity abnormalities may be a biological traits of major depression disorder and may be affected by the illness course.