中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2008年
3期
212-214
,共3页
李牧蔚%杨蕾%高传玉%沈玉祥%马业新
李牧蔚%楊蕾%高傳玉%瀋玉祥%馬業新
리목위%양뢰%고전옥%침옥상%마업신
冠状动脉疾病%应激,心理学%炎症因子
冠狀動脈疾病%應激,心理學%炎癥因子
관상동맥질병%응격,심이학%염증인자
Coronary disease%Stress,psychology%Inflammatory factors
目的 分析心理应激与急性冠状动脉综合征(ACS)的关系,探讨心理应激是否为诱发ACS发生的危险因素.方法 100例经冠状动脉造影检查及临床表现确诊为冠心病的中青年男性患者,分为ACS组(67例)和稳定性心绞痛(SA)组(33例),进行社会心理应激调查,测定其血清白介素(IL)-6、可溶性细胞间黏附分子(sICAM)-1及C-反应蛋白(CRP)的水平,并对其结果进行对照性分析.结果 (1)心理应激组52例,ACS患者和SA患者分别占78.8%(41例)和21.2%(11例,P=0.009);ACS组有心理应激者明显高于SA组[61.2%(41/67)比33.3%(11/33),P=0.009].(2)心理应激组的血清CRP[(14.82±5.07)g/L比(8.78±4.34)g/L]、IL-6[(101.7±22.2)ng/L比(71.1±23.5)ng/L]及sICAM-1[1(1.41±0.47)mg/L比(0.82±0.37)mg/L]明显高于非心理应激组(均P＜0.01);ACS组血清CRP[(18.91±3.12)g/L比(6.20±2.46)g/L]、IL-6[(114.6±15.2)ng/L比(56.4±15.8)ng/L]及sICAM-1[(1.67±0.39)mg/L比(0.63±0.28)mg/L]水平明显高于SA组(P＜0.01).结论 心理应激可使体内炎症因子分泌增加,从而使动脉粥样硬化斑块由稳定变成不稳定,并通过炎症反应参与了ACS发生、发展.
目的 分析心理應激與急性冠狀動脈綜閤徵(ACS)的關繫,探討心理應激是否為誘髮ACS髮生的危險因素.方法 100例經冠狀動脈造影檢查及臨床錶現確診為冠心病的中青年男性患者,分為ACS組(67例)和穩定性心絞痛(SA)組(33例),進行社會心理應激調查,測定其血清白介素(IL)-6、可溶性細胞間黏附分子(sICAM)-1及C-反應蛋白(CRP)的水平,併對其結果進行對照性分析.結果 (1)心理應激組52例,ACS患者和SA患者分彆佔78.8%(41例)和21.2%(11例,P=0.009);ACS組有心理應激者明顯高于SA組[61.2%(41/67)比33.3%(11/33),P=0.009].(2)心理應激組的血清CRP[(14.82±5.07)g/L比(8.78±4.34)g/L]、IL-6[(101.7±22.2)ng/L比(71.1±23.5)ng/L]及sICAM-1[1(1.41±0.47)mg/L比(0.82±0.37)mg/L]明顯高于非心理應激組(均P＜0.01);ACS組血清CRP[(18.91±3.12)g/L比(6.20±2.46)g/L]、IL-6[(114.6±15.2)ng/L比(56.4±15.8)ng/L]及sICAM-1[(1.67±0.39)mg/L比(0.63±0.28)mg/L]水平明顯高于SA組(P＜0.01).結論 心理應激可使體內炎癥因子分泌增加,從而使動脈粥樣硬化斑塊由穩定變成不穩定,併通過炎癥反應參與瞭ACS髮生、髮展.
목적 분석심리응격여급성관상동맥종합정(ACS)적관계,탐토심리응격시부위유발ACS발생적위험인소.방법 100례경관상동맥조영검사급림상표현학진위관심병적중청년남성환자,분위ACS조(67례)화은정성심교통(SA)조(33례),진행사회심리응격조사,측정기혈청백개소(IL)-6、가용성세포간점부분자(sICAM)-1급C-반응단백(CRP)적수평,병대기결과진행대조성분석.결과 (1)심리응격조52례,ACS환자화SA환자분별점78.8%(41례)화21.2%(11례,P=0.009);ACS조유심리응격자명현고우SA조[61.2%(41/67)비33.3%(11/33),P=0.009].(2)심리응격조적혈청CRP[(14.82±5.07)g/L비(8.78±4.34)g/L]、IL-6[(101.7±22.2)ng/L비(71.1±23.5)ng/L]급sICAM-1[1(1.41±0.47)mg/L비(0.82±0.37)mg/L]명현고우비심리응격조(균P＜0.01);ACS조혈청CRP[(18.91±3.12)g/L비(6.20±2.46)g/L]、IL-6[(114.6±15.2)ng/L비(56.4±15.8)ng/L]급sICAM-1[(1.67±0.39)mg/L비(0.63±0.28)mg/L]수평명현고우SA조(P＜0.01).결론 심리응격가사체내염증인자분비증가,종이사동맥죽양경화반괴유은정변성불은정,병통과염증반응삼여료ACS발생、발전.
Objective To observe the psychological stress status in patients with acute coronarysyndrome(ACS)and stable angina pectoris(SA).Methods The intensity of social psychological stress and the Serum levels of IL-6,CRP and ICAM-1 were determined in patients with ACS(n=67)and SA (n=33).Results(1)The percentage of patients with psychological stress was significantly higher in ACS than that in SA group(78.8% vs.21.2%,P＜0.01).(2)The serum levels of CRP[(14.82±5.07)g/L vs.(8.78±4.34)g/L],IL-6[(101.7±22.2)ng/L vs.(71.1±23.5)ng/L]and sICAM-1[(1.41±0.47)mg/L vs.(0.82±0.37)mg/L]were significantly higher in psychological stress group than those in non-psychological stress group(all P＜0.05).Serm CRP[(18.91±3.12)g/L vs.(6.20±2.46)g/L],IL-6[(114.6±15.2)ng/L vs.(56.4±15.8)ng/L]and sICAM-1[(1.67±0.39)mg/L vs.(0.63±0.28)mg/L]levels in ACS group were significantly higher than those in SA group(all P＜0.01).Conclusion Higher psychological stress was associated with higher risk of ACS and increased serum inflammatory cytokines.
