CAJ | 학술논문

细胞治疗是指将干细胞或由其分化产生的功能细胞植入病变部位代偿病变细胞丧失的功能,或将细胞经体外遗传操作后用于疾病治疗的方法.经过30多年的研究,肝细胞移植技术获得重大进展,可以起到原位肝移植同样的整体器官替代效果.肝细胞移植作为治疗暴发性肝衰竭的一种有效的方法在各种动物模型及临床应用中得到广泛证实.此外,应用治疗性肝干细胞可克服肝细胞的来源和数量、免疫排斥等问题,在治疗急慢性肝病有非常广阔的前景.由于肝干细胞研究还有许多问题,到目前为止,动物肝干细胞移植的研究资料较多.而应用该技术治疗人体肝病的病例数报道较少,对于人的肝干细胞研究尚属初步阶段,研究方法有待进一步发展和完善.
세포치료시지장간세포혹유기분화산생적공능세포식입병변부위대상병변세포상실적공능,혹장세포경체외유전조작후용우질병치료적방법.경과30다년적연구,간세포이식기술획득중대진전,가이기도원위간이식동양적정체기관체대효과.간세포이식작위치료폭발성간쇠갈적일충유효적방법재각충동물모형급림상응용중득도엄범증실.차외,응용치료성간간세포가극복간세포적래원화수량、면역배척등문제,재치료급만성간병유비상엄활적전경.유우간간세포연구환유허다문제,도목전위지,동물간간세포이식적연구자료교다.이응용해기술치료인체간병적병례수보도교소,대우인적간간세포연구상속초보계단,연구방법유대진일보발전화완선.
Cell therapy refers to a method that transplants stem cells or differentiated functioning cells into diseased regions to compensate the losing functions of diseased cells or uses the stem cells for treatment of diseases after in vitro genetic manipulation. After more than 30 years of study, great progress in hepatocyte transplantation technique has been acquired. This technique can acquire in situ liver transplantation effects. Hepatocyte transplantation, as an effective method for treatment of fulminant hepatic failure, has been widely confirmed in the animal model experiments and clinical practice. In addition, application of remedial hepatic stem cells can solve the problems regarding the source, number and immune rejection of hepatocytes, and offers a wide prospect for treatment of acute and chronic liver diseases. There are many problems about the study on hepatic stem cells. Up to date, many manuscripts addressing animal hepatic stem cell transplantation have been found, but few of them focus on the case report of treatment of liver disease by hepatocyte transplantation. Therefore, study on hepatic stem cells is still in its initial stage. The study methods should be developed and improved.