国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2010年
1期
26-28
,共3页
卵巢肿瘤%蛋白质阵列分析%诊断
卵巢腫瘤%蛋白質陣列分析%診斷
란소종류%단백질진렬분석%진단
proteomics%ovarian cancer%Meta analysis
目的 系统评价表面增强激光解吸电离飞行时间质谱技术(SELDI-TOF-MS)对卵巢癌的诊断效能.方法 检索1999年1月～2007年12月万方数据库、维普数据库和PUBMED数据库中关于利用SELDI-TOF-MS技术诊断卵巢癌的中英文文献.对纳入文献进行质量评价、异质性榆验和meta分析,用SPSS13.0软件计算综合受试者工作特征(SROC)曲线方程、灵敏度、特异度和综合优势比.结果 榆索到相关文献22篇,其中8篇文献被纳入,样本量739例,灵敏度、特异度和综合优势比分别为91.4%、99.5%、30.88,SROC曲线下面积为0.822 5.结论 SELDI-TOF-MS技术对卵巢癌诊断具有重要诊断价值.
目的 繫統評價錶麵增彊激光解吸電離飛行時間質譜技術(SELDI-TOF-MS)對卵巢癌的診斷效能.方法 檢索1999年1月～2007年12月萬方數據庫、維普數據庫和PUBMED數據庫中關于利用SELDI-TOF-MS技術診斷卵巢癌的中英文文獻.對納入文獻進行質量評價、異質性榆驗和meta分析,用SPSS13.0軟件計算綜閤受試者工作特徵(SROC)麯線方程、靈敏度、特異度和綜閤優勢比.結果 榆索到相關文獻22篇,其中8篇文獻被納入,樣本量739例,靈敏度、特異度和綜閤優勢比分彆為91.4%、99.5%、30.88,SROC麯線下麵積為0.822 5.結論 SELDI-TOF-MS技術對卵巢癌診斷具有重要診斷價值.
목적 계통평개표면증강격광해흡전리비행시간질보기술(SELDI-TOF-MS)대란소암적진단효능.방법 검색1999년1월～2007년12월만방수거고、유보수거고화PUBMED수거고중관우이용SELDI-TOF-MS기술진단란소암적중영문문헌.대납입문헌진행질량평개、이질성유험화meta분석,용SPSS13.0연건계산종합수시자공작특정(SROC)곡선방정、령민도、특이도화종합우세비.결과 유색도상관문헌22편,기중8편문헌피납입,양본량739례,령민도、특이도화종합우세비분별위91.4%、99.5%、30.88,SROC곡선하면적위0.822 5.결론 SELDI-TOF-MS기술대란소암진단구유중요진단개치.
Objective To assess overall diagnostic value of SELDI-TOF-MS in early breast cancer. Methods To search and identify the relevent articals in English and Chinese from Jan. 1999 to Dec. 2007 on Medline,WeiPu full-text data base and Wan-Fang clara base, and the literatures have been integrated to review the quality rating, and the heterology examination and the meta analysis were conducted. While the summary receiver operating characteristic curve (SROC), pooled sensitivity, specificity and odds rate were calculated by SPSS13.0 software. Results 22 pertinent literatures can be indexed as a whole, of which 8 articles in-cluding 739 samples entered this Meta analysis. The pooled sensitivity, specificity and odds rate were 91.4% ,99.5% and 30.88 re-spectively. The area under the SROC curve was 0. 822 5. Conclusion SELDI-TOF-MS is valuable in diagnosis of ovarian cancer.
