CAJ | 학술논문

背景:作者既往研究发现海藻酸多糖衍生物有促进骨细胞生长的作用.目的:探索海藻酸多糖衍生物治疗骨质疏松的效果.方法:60 只Wistar 雌性大鼠随机分成对照组,治疗组和模型组,每组20 只.治疗组和模型组大鼠用维甲酸诱导产生骨质疏松模型.治疗组大鼠每只每公斤每天10 mg 多糖衍生物灌胃,模型组每只每公斤每天10 mg 葡萄糖灌胃,持续2 周.观察大鼠股骨病理形态学和骨组织形态计量学变化.结果与结论:与对照组相比,模型组大鼠股骨骨小梁面积、平均骨小梁厚度、骨小梁密度显著降低,而髓腔质间隔宽度则明显增加;经过海藻多糖衍生物治疗后,治疗组大鼠股骨平均骨小梁密度,平均骨小梁厚度和骨小梁面积较模型组均显著上升,同时髓腔质间隔宽度明显下降;说明海藻酸性多糖能有效促进骨细胞生长,可治疗和预防骨质疏松.
배경:작자기왕연구발현해조산다당연생물유촉진골세포생장적작용.목적:탐색해조산다당연생물치료골질소송적효과.방법:60 지Wistar 자성대서수궤분성대조조,치료조화모형조,매조20 지.치료조화모형조대서용유갑산유도산생골질소송모형.치료조대서매지매공근매천10 mg 다당연생물관위,모형조매지매공근매천10 mg 포도당관위,지속2 주.관찰대서고골병리형태학화골조직형태계량학변화.결과여결론:여대조조상비,모형조대서고골골소량면적、평균골소량후도、골소량밀도현저강저,이수강질간격관도칙명현증가;경과해조다당연생물치료후,치료조대서고골평균골소량밀도,평균골소량후도화골소량면적교모형조균현저상승,동시수강질간격관도명현하강;설명해조산성다당능유효촉진골세포생장,가치료화예방골질소송.
BACKGROUND: We have previously reported that marine algae polysaccharide derivant can significantly promote bone cell growth.OBJECTIVE: To observe the effect of marin algae polysaccharide derivant in treatment of osteoporosis.METHODS: Sixty female Wistar rats were randomly divided into control group, treatment group and model group. There were 20 rats in each group. The rats in treatment group and model group were respectively treated with retinoic acid to induce osteoporosis. The rats in treatment group were gavaged the marine algae polysaccharide derivant 10 mg/kg, and the rats in model group were gavaged the glucose 10 mg/kg orally for 14 days. Changes of rat femur bone histological examination and histomorphometry parameters were observed.RESULTS AND CONCLUSION: The mean Trabecular Number (Tb.N), the mean Trabecular Thickness (Tb.Th) and the percent Trabecular Area (Tb.Ar%) were significantly decreased in the model group compared with control group. The mean trabecular separation (Tb.Sp) was greatly increased. After intake of marine algae polysaccharide derivant, Tb.N, Tb.Th and Tb.Ar% of the treatment group were significantly more than that of the model group. The Tb.Sp was obviously reduced. These indicate that marine algae polysaccharide derivant can increase bone mass and have a therapeutic and preventional effect on the osteoporosis.