中华细胞与干细胞杂志（电子版）
中華細胞與榦細胞雜誌（電子版）
중화세포여간세포잡지（전자판）
CHINESE JOURNAL OF CELL AND STEM CELL
2011年
2期
47-51
,共5页
许忆峰%杨晓凤%吴雁翔%王红梅%张轶斌%吕乃武%单鸿%崔激平%周金旭
許憶峰%楊曉鳳%吳雁翔%王紅梅%張軼斌%呂迺武%單鴻%崔激平%週金旭
허억봉%양효봉%오안상%왕홍매%장질빈%려내무%단홍%최격평%주금욱
缺血性下肢血管病%自体移植%骨髓单个核细胞
缺血性下肢血管病%自體移植%骨髓單箇覈細胞
결혈성하지혈관병%자체이식%골수단개핵세포
Ischemic disease of lower extremity%Autologus plantation%Mononuclear bone marrow cell
目的 探讨自体骨髓单个核细胞移植在下肢缺血性疾病治疗中的应用并评价其疗效.方法 回顾性总结分析解放军第四六三医院细胞治疗中心2003年11月至2008年8月住院的具有完整随访资料的下肢缺血性疾病患者254例,经动员后采集及分离自体骨髓,行下肢自体骨髓单个核细胞移植术.随访时间为1年.术后随访指标:3、6、12个月后复查皮温、深感觉、经皮氧分压和踝肱比,随访疼痛、冷感和跛行距离,观察溃疡和坏疽情况.采用F检验分析差异的统计学意义.结果 完成随访254例患者.(1)患者的疼痛缓解率为61.8％(157例/254例),冷感缓解率缓解率74.0％(188例/254例),跛行好转率40.2％(102例/254例),溃疡好转率59.0％ (36例/61例),坏疽截肢6例,脱落愈合5例,无变化8例,扩大7例；(2)患者下肢皮温由32.89℃±2.19℃上升至35.52℃±2.26℃(t=13.32,P=0.000),深感觉缓解由(26.20±15.78)mV下降至(20.34±10.86)mV(t=4.901,P=0.000),经皮氧分压由(26.46±18.49) mm Hg上升至(34.14±14.99)mm Hg(t=5.157,P=0.000),踝肱比由0.62±0.36上升至0.84±0.24(t=8.104,P=0.000).结论 骨髓单个核细胞移植治疗下肢缺血性血管病有效,是一种简单的、有效的治疗下肢动脉缺血性疾病的方法.
目的 探討自體骨髓單箇覈細胞移植在下肢缺血性疾病治療中的應用併評價其療效.方法 迴顧性總結分析解放軍第四六三醫院細胞治療中心2003年11月至2008年8月住院的具有完整隨訪資料的下肢缺血性疾病患者254例,經動員後採集及分離自體骨髓,行下肢自體骨髓單箇覈細胞移植術.隨訪時間為1年.術後隨訪指標:3、6、12箇月後複查皮溫、深感覺、經皮氧分壓和踝肱比,隨訪疼痛、冷感和跛行距離,觀察潰瘍和壞疽情況.採用F檢驗分析差異的統計學意義.結果 完成隨訪254例患者.(1)患者的疼痛緩解率為61.8％(157例/254例),冷感緩解率緩解率74.0％(188例/254例),跛行好轉率40.2％(102例/254例),潰瘍好轉率59.0％ (36例/61例),壞疽截肢6例,脫落愈閤5例,無變化8例,擴大7例；(2)患者下肢皮溫由32.89℃±2.19℃上升至35.52℃±2.26℃(t=13.32,P=0.000),深感覺緩解由(26.20±15.78)mV下降至(20.34±10.86)mV(t=4.901,P=0.000),經皮氧分壓由(26.46±18.49) mm Hg上升至(34.14±14.99)mm Hg(t=5.157,P=0.000),踝肱比由0.62±0.36上升至0.84±0.24(t=8.104,P=0.000).結論 骨髓單箇覈細胞移植治療下肢缺血性血管病有效,是一種簡單的、有效的治療下肢動脈缺血性疾病的方法.
목적 탐토자체골수단개핵세포이식재하지결혈성질병치료중적응용병평개기료효.방법 회고성총결분석해방군제사륙삼의원세포치료중심2003년11월지2008년8월주원적구유완정수방자료적하지결혈성질병환자254례,경동원후채집급분리자체골수,행하지자체골수단개핵세포이식술.수방시간위1년.술후수방지표:3、6、12개월후복사피온、심감각、경피양분압화과굉비,수방동통、랭감화파행거리,관찰궤양화배저정황.채용F검험분석차이적통계학의의.결과 완성수방254례환자.(1)환자적동통완해솔위61.8％(157례/254례),랭감완해솔완해솔74.0％(188례/254례),파행호전솔40.2％(102례/254례),궤양호전솔59.0％ (36례/61례),배저절지6례,탈락유합5례,무변화8례,확대7례；(2)환자하지피온유32.89℃±2.19℃상승지35.52℃±2.26℃(t=13.32,P=0.000),심감각완해유(26.20±15.78)mV하강지(20.34±10.86)mV(t=4.901,P=0.000),경피양분압유(26.46±18.49) mm Hg상승지(34.14±14.99)mm Hg(t=5.157,P=0.000),과굉비유0.62±0.36상승지0.84±0.24(t=8.104,P=0.000).결론 골수단개핵세포이식치료하지결혈성혈관병유효,시일충간단적、유효적치료하지동맥결혈성질병적방법.
Objective To evaluate the efficiency of autologous bone mononuclear cell (ABMC) transplantation in the treatment of ischemic disease of lower extremity.Methods Treatment records of 254 patients with ischemic disease of lower extremity were retrieved.All patients have been followed up for one year from November 2003 to August 2008.The skin temperature,bathesthesia,transcutaneous partial pressure O2 (TcPo2) and ankle -brachial index (ABI) were rechecked at 3,6 and 12 months after transplantation,and the symptoms of pain,cold,intermittent claudication and ulcer and gangrene were evaluated.Results A total of 254patients were evaluated.(1)Alleviation of pain and cold was reported in 61.8 ％ (157/254) and 74 ％ (188/254) of the patients respectively.Improvement of claudication was noted in 40.2 ％(102/254).Alleviation of ulcer was noted in 59 ％ (36/61).Six patients received amputation due to gangrene,5 patients healed by ablation,8 patients were stable and 7 patients have worsened ischemia.(2)The skin temperature of lower extremity increased from 32.89℃ ± 2.19℃ to 35.52℃ ± 2.26℃ (t=13.32,P=0.000),TcPo2 increased from (26.46 ± 18.49) mmHg to (34.14 ± 14.99 ) mmHg (t=5.157,P=0.000).The ABI increased from (0.62 ± 0.36) to (0.84 ± 0.24)(t=8.104,P=0.000).Conclusion ABMC transplantation is effective in the treatment of ischemic disease of lower extremity.
