CAJ | 학술논문

目的调查双相障碍患者治疗过程中代谢综合征(MetS)的发生情况并分析其生活方式.方法收集148例双相障碍患者的体质量指数(BMI)、血糖、血压、甘油三酯(TG)、高密度脂蛋白(HDL-C)等资料,并采用自制量表评估其生活方式,随访6月,与65例正常对照组进行比较.结果病例组在基线期、治疗1月、3月、6月MetS发生情况分别为:17例(11.5%)、23例(15.5%)、27例(18.2%)、31例(20.9%);病例组各个阶段MetS、BMI异常、高TG血症、低HDL-C血症、高血压发生率显著高于对照组(P<O.01);病例组治疗6月后MetS、高TG血症发生率均显著高于基线期(P<0.05);病例组各个阶段MetS发生率显著高于对照组(P<0.01,P<0.05);治疗6月后MetS发生率均显著高于基线期(P<0.05).病例组工作强度、体育锻炼频率、每日进食多餐的人数比例与对照组相比均差异有显著性(P<0.01,P<0.05).结论双相障碍患者代谢综合征发生率高于正常对照组;随着治疗的延续,代谢异常的发生率逐渐上升;不良的生活方式也可能是导致患者出现代谢异常的原因.
목적 조사쌍상장애환자치료과정중대사종합정(MetS)적발생정황병분석기생활방식.방법 수집148례쌍상장애환자적체질량지수(BMI)、혈당、혈압、감유삼지(TG)、고밀도지단백(HDL-C)등자료,병채용자제량표평고기생활방식,수방6월,여65례정상대조조진행비교.결과 병례조재기선기、치료1월、3월、6월MetS발생정황분별위:17례(11.5%)、23례(15.5%)、27례(18.2%)、31례(20.9%);병례조각개계단MetS、BMI이상、고TG혈증、저HDL-C혈증、고혈압발생솔현저고우대조조(P<O.01);병례조치료6월후MetS、고TG혈증발생솔균현저고우기선기(P<0.05);병례조각개계단MetS발생솔현저고우대조조(P<0.01,P<0.05);치료6월후MetS발생솔균현저고우기선기(P<0.05).병례조공작강도、체육단련빈솔、매일진식다찬적인수비례여대조조상비균차이유현저성(P<0.01,P<0.05).결론 쌍상장애환자대사종합정발생솔고우정상대조조;수착치료적연속,대사이상적발생솔축점상승;불량적생활방식야가능시도치환자출현대사이상적원인.
Objective To explore the prevalence of metabolic syndrome( MetS) and its components in patients with bipolar disorder and their lifestyle. Methods Collected 148 cases of bipolar disorder in patients with body mass index (BMI),blood glucose,blood pressure,triglyceride(TG),high-density lipoprotein( HDL-C) etc, and self-compiled scale was used to assess their lifestyle. All patients were followed 6 months. The patients werecompared with 65 normal controls. Results The patients group in the baseline period,treatment after 1 months,3 months and 6 months,the incidence of MetS was as followed:11.5% ,15.5% ,18.2% ,20.9%. The patients at all stages,the incidence of MetS,BMI≥25kg/m2 ,high TG levels,low HDL-C levels and hypertension were significantly higher than the control (P<0.01). After 6 months of treatment the incidence of MetS,hypertriglyceridemia were higher than baseline (P < 0.05). The patients group' s work intensity, frequency of exercise, eat more than 3 times per day compared with the control group were significantly different (P<0.01, P<0.05). Conclusion The incidence of MetS and hyperuricemia in patients with bipolar disorder after treatment is higher than the control group; as a continuation of the treatment,the incidence of metabolic abnormalities increased gradually. Unhealthy lifestyle, lack of exercise,unreasonable diet maybe increase the risk of metabolic disorders.