中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2008年
4期
244-247
,共4页
刘娜%王学民%卢宝荣%陈曦%Mauricio Odio%周玉田%吴琰瑜%谈益妹%万向红%陈聪
劉娜%王學民%盧寶榮%陳晞%Mauricio Odio%週玉田%吳琰瑜%談益妹%萬嚮紅%陳聰
류나%왕학민%로보영%진희%Mauricio Odio%주옥전%오염유%담익매%만향홍%진총
皮肤%人工合成尿液%经表皮失水率
皮膚%人工閤成尿液%經錶皮失水率
피부%인공합성뇨액%경표피실수솔
skin%Synthetic urine%TEWL
目的 观察不同pH值的人工合成尿液对皮肤表面pH值的影响.方法 分别应用pH2.0,3.5,5.0,6.5,8.0和10.0的人工合成尿液、蒸馏水和0.25%十二烷基硫酸钠水溶液对敏感性皮肤和正常皮肤行4h,20h,24h三个阶段的封闭型斑贴试验,应用临床评估、皮肤表面pH值和TEWL值来评判皮肤反应.结果 敏感性皮肤和正常皮肤对各种溶液的反应相似.两种pH仪测量皮肤表面pH值排列顺序与原溶液的pH值顺序相同.不同pH值的人工合成尿液改变了皮肤表面pH值,而且这种改变在斑贴去除后24h仍然存在.各人工合成尿液的TEWL值均不高于蒸馏水.只有72h pH 6.5,8.0和10.0的人工合成尿液的临床反应高于蒸馏水.结论 不同pH值的人工合成尿液改变皮肤表面pH值,pH 2.0～pH 10.0的人工合成尿液对人体皮肤的安全性与蒸馏水相似.
目的 觀察不同pH值的人工閤成尿液對皮膚錶麵pH值的影響.方法 分彆應用pH2.0,3.5,5.0,6.5,8.0和10.0的人工閤成尿液、蒸餾水和0.25%十二烷基硫痠鈉水溶液對敏感性皮膚和正常皮膚行4h,20h,24h三箇階段的封閉型斑貼試驗,應用臨床評估、皮膚錶麵pH值和TEWL值來評判皮膚反應.結果 敏感性皮膚和正常皮膚對各種溶液的反應相似.兩種pH儀測量皮膚錶麵pH值排列順序與原溶液的pH值順序相同.不同pH值的人工閤成尿液改變瞭皮膚錶麵pH值,而且這種改變在斑貼去除後24h仍然存在.各人工閤成尿液的TEWL值均不高于蒸餾水.隻有72h pH 6.5,8.0和10.0的人工閤成尿液的臨床反應高于蒸餾水.結論 不同pH值的人工閤成尿液改變皮膚錶麵pH值,pH 2.0～pH 10.0的人工閤成尿液對人體皮膚的安全性與蒸餾水相似.
목적 관찰불동pH치적인공합성뇨액대피부표면pH치적영향.방법 분별응용pH2.0,3.5,5.0,6.5,8.0화10.0적인공합성뇨액、증류수화0.25%십이완기류산납수용액대민감성피부화정상피부행4h,20h,24h삼개계단적봉폐형반첩시험,응용림상평고、피부표면pH치화TEWL치래평판피부반응.결과 민감성피부화정상피부대각충용액적반응상사.량충pH의측량피부표면pH치배렬순서여원용액적pH치순서상동.불동pH치적인공합성뇨액개변료피부표면pH치,이차저충개변재반첩거제후24h잉연존재.각인공합성뇨액적TEWL치균불고우증류수.지유72h pH 6.5,8.0화10.0적인공합성뇨액적림상반응고우증류수.결론 불동pH치적인공합성뇨액개변피부표면pH치,pH 2.0～pH 10.0적인공합성뇨액대인체피부적안전성여증류수상사.
Objective To investigate the impact of synthetic urine (synurine solution) at different pH values on skin surface.Methods Sixty-four healthy volunteers were enrolled into this study.Based on the results of lactic acid test and questionaires,these subjects were enrolled as sensitive skin group and normal skin group.The 4-,20-,and 24-hour occlusive patch tests were successively performed with synthetic urine at various pH values (2.0,3.5,5.0,6.5,8.0 and 10.0)on the two groups of volunteers.The distilled water and 0.25%sodium lauryl sulphate (SLS)served as control.The skin surface pH values were measured bypotable pH meter before,and at 24 h,48 h,72 h after the first patch.Half an hour after the latter three detections of pH values,the skin response was evaluated clinically,as well as by transepidermal water loss (TEWL)and pH values,which were measured by pH-900 pH Meter.Results The responses to these solutions were similar between sensitive and normal skin groups.The order of skin surface pH values measured by the two pH meters was consistent with that of the original solutions.The skin surface pH value was altered by the synthetic urine,and this change was still present at 24 hours after the patches were removed.The TEWL values of skin challenged by synthetic urine were not higher than those by distilled water.The skin responses at 72 hours were more intense to the synthetic urines with pH values of.5,8.0,10.0than to distilled water.Condusions Synthetic urines with different pH values can alter skin surface pH values,and skin responses to synthetic urines with a pH range 2.0-10.0 are similar to those to distilled water.
