国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2010年
11期
831-835
,共5页
二膦酸盐类%血管生成抑制剂
二膦痠鹽類%血管生成抑製劑
이련산염류%혈관생성억제제
Diphosphonates%Angiogenesis inhibitors
双膦酸盐具有直接抗肿瘤和抗血管形成作用,具体机制仍未肯定.现有研究认为双膦酸盐通过干扰甲羟戊酸信号通路的关键激酶,使小G蛋白异戊酸化受阻等机制抑制内皮祖细胞分化和小管样形成,阻止血管发生;抑制血管内皮细胞的增殖、黏附和迁移能力,干扰血管形成;调节肿瘤血管形成细胞因子分泌,抑制血管形成相关基因等功能发挥其抗血管形成作用.
雙膦痠鹽具有直接抗腫瘤和抗血管形成作用,具體機製仍未肯定.現有研究認為雙膦痠鹽通過榦擾甲羥戊痠信號通路的關鍵激酶,使小G蛋白異戊痠化受阻等機製抑製內皮祖細胞分化和小管樣形成,阻止血管髮生;抑製血管內皮細胞的增殖、黏附和遷移能力,榦擾血管形成;調節腫瘤血管形成細胞因子分泌,抑製血管形成相關基因等功能髮揮其抗血管形成作用.
쌍련산염구유직접항종류화항혈관형성작용,구체궤제잉미긍정.현유연구인위쌍련산염통과간우갑간무산신호통로적관건격매,사소G단백이무산화수조등궤제억제내피조세포분화화소관양형성,조지혈관발생;억제혈관내피세포적증식、점부화천이능력,간우혈관형성;조절종류혈관형성세포인자분비,억제혈관형성상관기인등공능발휘기항혈관형성작용.
Bisphosphonates have shown direct anti-tumor and anti-angiogenesis effects, but the exact mechanism has not yet been elucidated. Based on the existing findings, some mechanisms related to the inhibition of vascularization has been proposed. First, bisphosphonates inhibit the differentiation of endothelial progenitor cells by interfering with the key enzyme in the mevalonate pathway which plays an important role in the prenylation of small G-proteins. Second,bisphosphonates impair the proliferation,adhesion and migration of endothelial cells. Last, bisphosphonates are able to regulate secretion of cytokines which are involved in angiogenesis and inhibit the functions of angiogenesis-related genes.
