CAJ | 학술논문

目的通过脑功能磁共振成像(functional magnetic resonance imaging,fMRI)技术检测健康人脑纹状体边缘区(marginal division of the striatum,MrD)是否参与联想学习记忆的过程.方法对16名右利手健康志愿者进行一项配对词语联想学习记忆任务的同时,进行fMRI扫描.试验采用组块设计并选用SPM 99软件进行数据分析和脑功能区定位.结果应用单样本t检验(SPM统计软件将体素的激活强度T值在数值上等于t检验的t值),当统计阈值设为P＜0.005时,左枕叶和左额上、中回在任务编码时被显著激活(最大激活强度分别为T=13.87、9.36),左纹状体边缘区也在该阶段被明显激活(T=5.46);而左顶叶则在记忆提取阶段被显著激活(T=8.73).结论除皮质外,皮质下结构如MrD也参与了词语联想学习记忆过程.
목적 통과뇌공능자공진성상(functional magnetic resonance imaging,fMRI)기술검측건강인뇌문상체변연구(marginal division of the striatum,MrD)시부삼여련상학습기억적과정.방법 대16명우리수건강지원자진행일항배대사어련상학습기억임무적동시,진행fMRI소묘.시험채용조괴설계병선용SPM 99연건진행수거분석화뇌공능구정위.결과 응용단양본t검험(SPM통계연건장체소적격활강도T치재수치상등우t검험적t치),당통계역치설위P＜0.005시,좌침협화좌액상、중회재임무편마시피현저격활(최대격활강도분별위T=13.87、9.36),좌문상체변연구야재해계단피명현격활(T=5.46);이좌정협칙재기억제취계단피현저격활(T=8.73).결론 제피질외,피질하결구여MrD야삼여료사어련상학습기억과정.
Objective To examine whether the marginal division of the striatum(MrD)is involved in the associative learning and memory function of human brain with the help of functional magnetic resonance imaging(fMRI)technique.Methods Sixteen right-handed normal volunteers participated in a test of paired-word associative learning and memory,while the fMRI data were recorded.Control tasks were performed for the block-design.Statistcs parameter mapping 99 was used to analyze the data and to obtain the activated brain regions.Results When the threshold was set as P＜0.005.using a one-sample T-test,the left occipital lobe and the superior and middle gyrus of the left frontal lobe were activated remarkably during the encoding process of the paired-word associative learning and memory task,with the maximum intensity T value being 13.87 and 9.36.respectively.The left MrD was also obviously activated during this stage(T value was 5.46).But during the retrieval process,the left parietal lobe was prominently activated(T value was 8.73).Conclusion The resuhs of this study reveal that the subcortical structures such as MrD as well as the cerebral cortex are involved in the associative learning and memory of paired-word in human brain.