中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2008年
5期
388-390
,共3页
肝炎%乙型%慢性%丙氨酸氨基转移酶%DNA%病理学
肝炎%乙型%慢性%丙氨痠氨基轉移酶%DNA%病理學
간염%을형%만성%병안산안기전이매%DNA%병이학
Hepatitis B%chronic%Alanine aminotransferase%DNA%Pathology
目的 探讨慢性HBV感染ALT、HBV DNA与肝脏病理的关系.方法 对81例慢性HBV感染患者检测血清ALT、HBV DNA.并进行肝活检病理检查.结果 肝脏炎症分级和纤维化分期与ALT明显相关(r值分别为0.683和0.419),与HBV DNA无相关性.随着肝脏炎症活动度和纤维化程度的加重,ALT有升高趋势(χ2趋势值分别为25.81和12.012),HBV DNA无升高趋势,而随着HBVDNA的升高,肝脏炎症活动度和纤维化程度并无加重趋势.肝组织HBsAg、HBcAg阳性组与阴性组的ALT、HBV DNA差异无统计学意义.结论 ALT与肝脏炎症活动度有明显相关性,仍是观察炎症变化的敏感指标,HBV DNA与肝组织炎症分级及纤维化分期无相关性.
目的 探討慢性HBV感染ALT、HBV DNA與肝髒病理的關繫.方法 對81例慢性HBV感染患者檢測血清ALT、HBV DNA.併進行肝活檢病理檢查.結果 肝髒炎癥分級和纖維化分期與ALT明顯相關(r值分彆為0.683和0.419),與HBV DNA無相關性.隨著肝髒炎癥活動度和纖維化程度的加重,ALT有升高趨勢(χ2趨勢值分彆為25.81和12.012),HBV DNA無升高趨勢,而隨著HBVDNA的升高,肝髒炎癥活動度和纖維化程度併無加重趨勢.肝組織HBsAg、HBcAg暘性組與陰性組的ALT、HBV DNA差異無統計學意義.結論 ALT與肝髒炎癥活動度有明顯相關性,仍是觀察炎癥變化的敏感指標,HBV DNA與肝組織炎癥分級及纖維化分期無相關性.
목적 탐토만성HBV감염ALT、HBV DNA여간장병리적관계.방법 대81례만성HBV감염환자검측혈청ALT、HBV DNA.병진행간활검병리검사.결과 간장염증분급화섬유화분기여ALT명현상관(r치분별위0.683화0.419),여HBV DNA무상관성.수착간장염증활동도화섬유화정도적가중,ALT유승고추세(χ2추세치분별위25.81화12.012),HBV DNA무승고추세,이수착HBVDNA적승고,간장염증활동도화섬유화정도병무가중추세.간조직HBsAg、HBcAg양성조여음성조적ALT、HBV DNA차이무통계학의의.결론 ALT여간장염증활동도유명현상관성,잉시관찰염증변화적민감지표,HBV DNA여간조직염증분급급섬유화분기무상관성.
Objective To study the relationship among pathological and immunohistochemical changes in liver tissue and alanine aminotransferase (ALT), HBV DNA levels in the patients with HBV infection. Methods The serum ALT, HBV DNA levels, pathological and immunohistochemistry examination of liver tissue were performed in 81 patients with chronic HBV infection. Results The correlation of liver inflammation grades or fibrosis stages and the serum ALT levels were observed (the correlation coefficient were 0.683 and 0.419, respectively), but not the HBV DNA levels. Followed by the hepatic inflammation activity and fibrosis, the serum ALT levels was obviously elevated, but the serum HBV DNA levels was not. The serum ALT, HBV DNA levels between the hepatic HBsAg/HBcAg positive group and HBsAg/HBcAg negative group were not different. Conclusion The serum ALT levels had significant relationship with the hepatitis activity, and ALT could be helpful for assessing the hepatitis activity. There was not correlation between hepatic inflammation grades and fibrosis stages and the serum HBV DNA, as well as the expression of HBsAg/HBcAg in liver tissue.
