肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
4期
254-255,258
,共3页
方江胜%王建荣%王剑华%刘俊生%胥枫林
方江勝%王建榮%王劍華%劉俊生%胥楓林
방강성%왕건영%왕검화%류준생%서풍림
膀胱肿瘤%p27kip1%CychnE%CyclinD1%膀胱移行细胞癌
膀胱腫瘤%p27kip1%CychnE%CyclinD1%膀胱移行細胞癌
방광종류%p27kip1%CychnE%CyclinD1%방광이행세포암
Urinary bladder neoplasms%p27kip1%CyclinE%CyclinD1%Bladder transitional cell carcinoma
目的 探讨p27kip1、CyclinE、CyclinD1在膀胱移行细胞癌(BTCC)中的表达与意义,为认识BTCC发生、发展机制提供线索.方法 应用免疫组织化学SP法检测41例BTCC和12例膀胱炎中p27kip1、CyclinE、CyclinD1的表达.结果 p27kip1在BTCC中阳性表达随临床分期和病理分级的增高而降低(P<0.05),有淋巴转移组与无淋巴转移组比较差异无统计学意义(P>0.05).CyclinD1在不同BTCC临床分期和病理分级中的阳性表达差异无统计学意义(P>0.05).CyclinE在BTCC中阳性表达随临床分期和病理分级的增高而增高(P<0.05),有淋巴转移组明显高于无淋巴转移组(P<0.05).结论 p27kip1对BTCC的发生、发展可能起抑制作用,CyclinD1过表达可能在膀胱移行细胞癌发生的早期起作用,不参与膀胱移行细胞癌的浸润转移过程.CyclinE可能参与BTCC的发生、发展过程.
目的 探討p27kip1、CyclinE、CyclinD1在膀胱移行細胞癌(BTCC)中的錶達與意義,為認識BTCC髮生、髮展機製提供線索.方法 應用免疫組織化學SP法檢測41例BTCC和12例膀胱炎中p27kip1、CyclinE、CyclinD1的錶達.結果 p27kip1在BTCC中暘性錶達隨臨床分期和病理分級的增高而降低(P<0.05),有淋巴轉移組與無淋巴轉移組比較差異無統計學意義(P>0.05).CyclinD1在不同BTCC臨床分期和病理分級中的暘性錶達差異無統計學意義(P>0.05).CyclinE在BTCC中暘性錶達隨臨床分期和病理分級的增高而增高(P<0.05),有淋巴轉移組明顯高于無淋巴轉移組(P<0.05).結論 p27kip1對BTCC的髮生、髮展可能起抑製作用,CyclinD1過錶達可能在膀胱移行細胞癌髮生的早期起作用,不參與膀胱移行細胞癌的浸潤轉移過程.CyclinE可能參與BTCC的髮生、髮展過程.
목적 탐토p27kip1、CyclinE、CyclinD1재방광이행세포암(BTCC)중적표체여의의,위인식BTCC발생、발전궤제제공선색.방법 응용면역조직화학SP법검측41례BTCC화12례방광염중p27kip1、CyclinE、CyclinD1적표체.결과 p27kip1재BTCC중양성표체수림상분기화병리분급적증고이강저(P<0.05),유림파전이조여무림파전이조비교차이무통계학의의(P>0.05).CyclinD1재불동BTCC림상분기화병리분급중적양성표체차이무통계학의의(P>0.05).CyclinE재BTCC중양성표체수림상분기화병리분급적증고이증고(P<0.05),유림파전이조명현고우무림파전이조(P<0.05).결론 p27kip1대BTCC적발생、발전가능기억제작용,CyclinD1과표체가능재방광이행세포암발생적조기기작용,불삼여방광이행세포암적침윤전이과정.CyclinE가능삼여BTCC적발생、발전과정.
Objective To investigate the expression of p27kip1, CyclinE, CyclinD1 in bladder transitional cell carcinoma (BTCC), and evaluate their relationship with turnout cell proliferation. Methods To study the expression of p27kip1, CyclinE and CyclinD1 protein in 41 cases of paraffin-embedded BTCC tissue and in 12 cases of cystitis tissues by immunohistochemical method SP. Results There was a negative relationship between p27kip1 expression and clinical stage and pathological grade.There was no relationship with lymph node metastasis (P>0.05). There was a positive relationship between CyclinE expression and clinical stage, pathological grade and lymph node metastasis (P<0.05). There was no relationship between CyclinD1 expression and clinical stage, pathological grade and lymph node metastasis (P>0.05). Conclusion The results of this study showed that the abnormal expression of p27kip1, CyclinE, may play important roles in the genesis and progression of BTCC. CyclinD1 may take activation in the early term of BTCC.
