CAJ | 학술논문

目的探讨p16、cyclinD1蛋白在食管鳞状细胞癌(ESCC)组织中的表达及其与临床病理之间的关系.方法应用免疫组织化学法,对55例手术切除的原发ESCC患者的肿瘤组织蜡块进行p16和cyclinD1蛋白的检测.结果55例ESCC患者中p16蛋白表达率为49.1%(27/55).p16蛋白缺失与淋巴结转移有一定的相关性(P＜0.05);p16表达阳性者5年生存率为71.4%(10/14).55例ESCC中cyclinD1蛋白表达率为74.5%(41/55),cyclinD1阳性表达患者的5年生存率低于阴性表达患者.结论ESCC患者的p16蛋白表达缺失较常见,p16蛋白的失表达与cyclinD1基因蛋白过表达在食管癌发生及转移过程中可能有协同作用,可作为判断预后的参考指标之一.
목적 탐토p16、cyclinD1단백재식관린상세포암(ESCC)조직중적표체급기여림상병리지간적관계.방법응용면역조직화학법,대55례수술절제적원발ESCC환자적종류조직사괴진행p16화cyclinD1단백적검측.결과55례ESCC환자중p16단백표체솔위49.1%(27/55).p16단백결실여림파결전이유일정적상관성(P＜0.05);p16표체양성자5년생존솔위71.4%(10/14).55례ESCC중cyclinD1단백표체솔위74.5%(41/55),cyclinD1양성표체환자적5년생존솔저우음성표체환자.결론ESCC환자적p16단백표체결실교상견,p16단백적실표체여cyclinD1기인단백과표체재식관암발생급전이과정중가능유협동작용,가작위판단예후적삼고지표지일.
Objective To investigate the expressions of p16, cyclinD1 protein in esophageal squamous cell carcinoma and its clinic significance. Methods The expressions of p16 and cyclinD1 protein in 55 esophageal carcinoma cases were detected by immunohistochemical technique. Results The positive expression of p16 protein in 55 patients was 49.1%(27/55). The loss of p16 protein was significantly related to lymph node metastasis (P ＜0.05), and the positive expression of p16 had the higher five-year survival rate.Conversely, the positive expression of cyclinD1 in 55 patients was 74.5 % (41/55), and had the lower five-year survival rate compared to the negative expression cases. Conclusion Loss of p16 protein in human ESCC is a frequent event and correlates significantly with the lymph node metastasis. The loss of p16 and the over expression of cyclinD 1 in esophageal carcinoma may serve as a risk prognosis factors.