CAJ | 학술논문

目的探讨肺癌肿瘤抑制物1 (TSLC1)和Wnt-1诱导分泌蛋白3(WISP-3)在非小细胞肺癌(NSCLC)组织中的表达及两者与NSCLC临床特征之间的关系.方法采用免疫组织化学法检测80例NSCLC患者手术切除的癌组织和癌旁组织中TSLC1和WISP-3表达水平.结果 TSLC1在NSCLC癌组织中的表达率为30.00％ (24/80),明显低于在癌旁组织中表达率71.25％ (57/80),两者差异有统计学意义(P＜0.01),WISP-3在NSCLC癌组织中的表达率为67.50％( 54/80),明显高于在癌旁组织中表达率16.25％ (13/80),两者差异有统计学意义(P＜0.01).TSLC1表达水平与NSCLC组织学分化程度、TNM分期、淋巴结转移有关(P＜0.05),WISP-3表达水平与NSCLC组织学分化程度、TNM分期、年龄明显相关(P＜0.05).结论 TSLC1和WISP-3可能参与NSCLC的发生发展,并可能是NSCLC预后相关指标.
목적 탐토폐암종류억제물1 (TSLC1)화Wnt-1유도분비단백3(WISP-3)재비소세포폐암(NSCLC)조직중적표체급량자여NSCLC림상특정지간적관계.방법 채용면역조직화학법검측80례NSCLC환자수술절제적암조직화암방조직중TSLC1화WISP-3표체수평.결과 TSLC1재NSCLC암조직중적표체솔위30.00％ (24/80),명현저우재암방조직중표체솔71.25％ (57/80),량자차이유통계학의의(P＜0.01),WISP-3재NSCLC암조직중적표체솔위67.50％( 54/80),명현고우재암방조직중표체솔16.25％ (13/80),량자차이유통계학의의(P＜0.01).TSLC1표체수평여NSCLC조직학분화정도、TNM분기、림파결전이유관(P＜0.05),WISP-3표체수평여NSCLC조직학분화정도、TNM분기、년령명현상관(P＜0.05).결론 TSLC1화WISP-3가능삼여NSCLC적발생발전,병가능시NSCLC예후상관지표.
Objective To investigate the expression of tumor suppressor in lung cancer 1 (TSLC1) and WISP-3 in non-small cell lung carcinoma ( NSCLC),and their relation to the clinicopathological features.Methods Envision immunohistochemical method were used to assess the expression of TSLC1 and WISP-3 in 80 cases of human NSCLC tissues and non-cancerous adjacent lung tissues.Results The expression rate of TSLC1 in was 30.00％ (24/80) in NSCLC tissues,and 71.25％ (57/80) in non-cancerous adjacent lung tissues ( P ＜ 0.01 ),the expression rate of WISP-3 was 67.50％ (54/80) in NSCLC tissues,and 16.25％ (13/80) in non-cancerous adjacent lung tissues (P ＜0.01 ).the expressions of TSLC1 were related to histology grade,TNM stage and lymph node metastasis (P ＜ 0.05 ),there was a close relation between the expression of WISP-3 and histology grade,TNM stage and age ( P ＜ 0.05 ).Conclusion TSLC1 and WISP-3 may participate in the development and progression of NSCLC,and may be used to predict the prognosis of NSCLC patients.