中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
7期
638-640
,共3页
袁媛%王航平%赵晓明%李大伟%刘华%刘坚%孙振武%周龙慧%但齐琴%王廷华
袁媛%王航平%趙曉明%李大偉%劉華%劉堅%孫振武%週龍慧%但齊琴%王廷華
원원%왕항평%조효명%리대위%류화%류견%손진무%주룡혜%단제금%왕정화
大鼠%游泳%肾上腺%腺脑源性神经因子%trkB
大鼠%遊泳%腎上腺%腺腦源性神經因子%trkB
대서%유영%신상선%선뇌원성신경인자%trkB
Rat%Swimming%Adrenal body%Brain derived neurotrophic factor%trkB
目的 研究游泳训练对大鼠运动行为及肾上腺脑源性神经营养因子(BDNF)及其受体trkB表达的影响.方法 成年SD大鼠按随机数字表分为2组,即正常对照组及游泳组(n=10/组),游泳组大鼠用水槽进行游泳训练,记录大鼠游泳轨迹,训练6周时测定单位时间内大鼠游泳速度和距离.同时用RT-PCR检测肾上腺BDNF及其trkB的表达变化.结果 与正常组比较[距离(156.92±29)m,速度(283±60) m/min],游泳训练明显提高大鼠运动行为[距离(283.36±49.50)m,速度(157±60) m/min],差异有统计学意义(P＜0.05)；游泳组大鼠肾上腺BDNF基因表达水平(0.93 ±0.09)明显较正常组(0.56±0.19)增加(P＜0.05),但trkB表达没有发生明显变化(P＞0.05).结论 游泳训练明显改进大鼠运动行为并上调肾上腺BDNF基因表达.
目的 研究遊泳訓練對大鼠運動行為及腎上腺腦源性神經營養因子(BDNF)及其受體trkB錶達的影響.方法 成年SD大鼠按隨機數字錶分為2組,即正常對照組及遊泳組(n=10/組),遊泳組大鼠用水槽進行遊泳訓練,記錄大鼠遊泳軌跡,訓練6週時測定單位時間內大鼠遊泳速度和距離.同時用RT-PCR檢測腎上腺BDNF及其trkB的錶達變化.結果 與正常組比較[距離(156.92±29)m,速度(283±60) m/min],遊泳訓練明顯提高大鼠運動行為[距離(283.36±49.50)m,速度(157±60) m/min],差異有統計學意義(P＜0.05)；遊泳組大鼠腎上腺BDNF基因錶達水平(0.93 ±0.09)明顯較正常組(0.56±0.19)增加(P＜0.05),但trkB錶達沒有髮生明顯變化(P＞0.05).結論 遊泳訓練明顯改進大鼠運動行為併上調腎上腺BDNF基因錶達.
목적 연구유영훈련대대서운동행위급신상선뇌원성신경영양인자(BDNF)급기수체trkB표체적영향.방법 성년SD대서안수궤수자표분위2조,즉정상대조조급유영조(n=10/조),유영조대서용수조진행유영훈련,기록대서유영궤적,훈련6주시측정단위시간내대서유영속도화거리.동시용RT-PCR검측신상선BDNF급기trkB적표체변화.결과 여정상조비교[거리(156.92±29)m,속도(283±60) m/min],유영훈련명현제고대서운동행위[거리(283.36±49.50)m,속도(157±60) m/min],차이유통계학의의(P＜0.05)；유영조대서신상선BDNF기인표체수평(0.93 ±0.09)명현교정상조(0.56±0.19)증가(P＜0.05),단trkB표체몰유발생명현변화(P＞0.05).결론 유영훈련명현개진대서운동행위병상조신상선BDNF기인표체.
Objective To explore the effect of swimming on motor behavior and expression of brain derived neurotrophic factor(BDNF) and trkB in adrenal body.Methods SD adult rats were divided into normal cotrol group and swimming group ( n=10 in each group).All rats in swimming group were subjected 6 weeks swimming for 1h each day.Motor performances including swimming speed and distance were recorded and expression of BDNF and trkB in adrenal body was measured.Results There was a significant increase in swimming speed ( ( 157 ± 60) m/min) and distance ( (283.36 ±49.50)m) in swimming group,compared with control group ( (283± 60) m/min,( 156.92 ± 29) m) (P ＜ 0.05 ).Simultaneously,expression of BDNF in adrenal body had been significantly unregulated (0.93 ± 0.09 vs 0.56 ± 0.19 ) (P ＜ 0.05 ),while expression of trkB kept to be not changed.Conclusion Swimming increases notor ability in rats,and the possible mechanism may be related the upregulation of BDNF in adrenal body.
