CAJ | 학술논문

目的评价小剂量肝素治疗热射病非显性DIC的疗效.方法将36例热射病非显性DIC患者随机分为2组,治疗组18例,对照组18例.两组均采用综合治疗,治疗组治疗前加用肝素70U/kg,24 h持续泵入,连用3 d.比较两组患者发生DIC的机率及病死率,观察治疗组应用肝素前后患者BPC,PT,APTT的变化情况.结果与对照组相比,治疗组DIC发生率及病死率明显降低(P＜0.05),治疗组治疗后BPC升高,有统计学意义(P＜0.01),PT,APTT差异无统计学意义(P＞0.05).结论应用小剂量肝素有效防止热射病非显性DIC向DIC的发展,降低死亡率.
목적 평개소제량간소치료열사병비현성DIC적료효.방법 장36례열사병비현성DIC환자수궤분위2조,치료조18례,대조조18례.량조균채용종합치료,치료조치료전가용간소70U/kg,24 h지속빙입,련용3 d.비교량조환자발생DIC적궤솔급병사솔,관찰치료조응용간소전후환자BPC,PT,APTT적변화정황.결과 여대조조상비,치료조DIC발생솔급병사솔명현강저(P＜0.05),치료조치료후BPC승고,유통계학의의(P＜0.01),PT,APTT차이무통계학의의(P＞0.05).결론 응용소제량간소유효방지열사병비현성DIC향DIC적발전,강저사망솔.
Objective To investigate the therapeutic effect and safety of low-dose heparin therapy for heat stroke with pre-diffuse intravascular coagulation (pre-DIC). Methods 35 cases of heat stroke with preDIC were randomly divided into two groups, 18 cases were treated with low-dose heparin therapy (treatment group, n = 22, given heparion by 70U/kg for 3 days, 24 hours of continuous pump), 17 cases were treated with conventional therapy(control group). The incidence of DIC and mortality in two groups were observed and compared. Results Incidence of DIC and mortality in treatment group were significant lower than those in control group(P ＜0. 05). After the treatment group therapy, a statistically significant increase BPC (P＜ 0. 01). No significant differences APTT PT, (P ＞ 0.05). Conclusion Low-dose heparion is applied early in heat stroke patients in pre-DIC stage, which could not only prevent efficiently DIC, but also diminish mortality.