中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
9期
3-5
,共3页
子痫%高血压%妊娠性%血液凝固
子癇%高血壓%妊娠性%血液凝固
자간%고혈압%임신성%혈액응고
Eclampsia%Hypertension,pregnancy-induced%Blood coagulation
目的 探讨妊娠期高血压疾病患者凝血指标变化的意义.方法 收集66例妊娠期高血压疾病患者(妊娠期高血压组)及70例正常妊娠晚期孕妇(对照组),行血小板计数(PC)、平均血小板体积(MPV)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)检测.结果妊娠期高血压组与对照组比较,PC[(178.32±51.08) × 10~9/L比(186.17±40.02)× 10~9/L]、PT[(10.54±0.54)s比(11.07±0.49)s]、APTT[(26.23±3.12)s比(28.08±4.31)s]显著下降(P<0.05或<0.01);FIB[(5.34±0.68)g/L比(4.02±0.73)g/L]、MPV[(11.10±2.31)fl比(8.95±1.37)fl]、D-D[(0.46±0.27)mg/L比(0.18±0.19)mg/L]显著增加(P<0.01).重度子痫前期患者与轻度子痫前期患者比较,FIB、D-D显著增加(P<0.01).早发型子痫前期患者与晚发型子痫前期患者比较,PT明显缩短(P<0.05),FIB、D-D明显增加(P<0.05或<0.01).结论 妊娠期高血压疾病呈明显高凝状态;早发型子痫前期患者较晚发型子痫前期患者高凝状态和凝血功能障碍更严重.
目的 探討妊娠期高血壓疾病患者凝血指標變化的意義.方法 收集66例妊娠期高血壓疾病患者(妊娠期高血壓組)及70例正常妊娠晚期孕婦(對照組),行血小闆計數(PC)、平均血小闆體積(MPV)、凝血酶原時間(PT)、部分凝血活酶時間(APTT)、纖維蛋白原(FIB)、D-二聚體(D-D)檢測.結果妊娠期高血壓組與對照組比較,PC[(178.32±51.08) × 10~9/L比(186.17±40.02)× 10~9/L]、PT[(10.54±0.54)s比(11.07±0.49)s]、APTT[(26.23±3.12)s比(28.08±4.31)s]顯著下降(P<0.05或<0.01);FIB[(5.34±0.68)g/L比(4.02±0.73)g/L]、MPV[(11.10±2.31)fl比(8.95±1.37)fl]、D-D[(0.46±0.27)mg/L比(0.18±0.19)mg/L]顯著增加(P<0.01).重度子癇前期患者與輕度子癇前期患者比較,FIB、D-D顯著增加(P<0.01).早髮型子癇前期患者與晚髮型子癇前期患者比較,PT明顯縮短(P<0.05),FIB、D-D明顯增加(P<0.05或<0.01).結論 妊娠期高血壓疾病呈明顯高凝狀態;早髮型子癇前期患者較晚髮型子癇前期患者高凝狀態和凝血功能障礙更嚴重.
목적 탐토임신기고혈압질병환자응혈지표변화적의의.방법 수집66례임신기고혈압질병환자(임신기고혈압조)급70례정상임신만기잉부(대조조),행혈소판계수(PC)、평균혈소판체적(MPV)、응혈매원시간(PT)、부분응혈활매시간(APTT)、섬유단백원(FIB)、D-이취체(D-D)검측.결과임신기고혈압조여대조조비교,PC[(178.32±51.08) × 10~9/L비(186.17±40.02)× 10~9/L]、PT[(10.54±0.54)s비(11.07±0.49)s]、APTT[(26.23±3.12)s비(28.08±4.31)s]현저하강(P<0.05혹<0.01);FIB[(5.34±0.68)g/L비(4.02±0.73)g/L]、MPV[(11.10±2.31)fl비(8.95±1.37)fl]、D-D[(0.46±0.27)mg/L비(0.18±0.19)mg/L]현저증가(P<0.01).중도자간전기환자여경도자간전기환자비교,FIB、D-D현저증가(P<0.01).조발형자간전기환자여만발형자간전기환자비교,PT명현축단(P<0.05),FIB、D-D명현증가(P<0.05혹<0.01).결론 임신기고혈압질병정명현고응상태;조발형자간전기환자교만발형자간전기환자고응상태화응혈공능장애경엄중.
Objective To investigate the changes of the hemostatie coagulation markers in pregnancy induced hypertension (PIH)and significance.Methods The blood samples were collected from 70 normal pregnant women (control group) and 66 pregnant women with PIH (PIH group).Platelet count (PC), mean platelet volume ( MPV ), prothrombin lime (PT), partial thromboplastin time (AFIT), fibrinogen (FIB),D-dimmer (D-D)were measured.Results Compared with the control group,the level of PC,PT, APTT in the PIH group were significantly decreased [(178.32±51.08) × 10~9/L vs (186.17±40.02) × 10~9/L, (10.54±0.34) s vs(11.07±0.49) s, (26.23±3.12) s vs(28.08±4.31) s](P<0.05 or <0.01), while those of FIB,MPV,D-D were significantly increased [(5.34±0.68) g/L vs (4.02±0.73) g/L, (11.10 ± 2.31 ) fl vs (8.95 ± 1.37) fl, (0.46 ± 0.27) mg/L vs (0.18 ± 0.19) mg/L](P < 0.01 ).The levels of FIB and D-D were significantly increased in severe preeclampsia (34 cases) than those in mild preeclampsia (32 cases) (P < 0.01 ).The level of PT was lower and FIB, D-D were increased in early onset preeclampsia ( 31 cases ) than those in late onset preeclampsia (35 cases) (P < 0.05 or < 0.01 ).Conclusions There is hypercoagulative state in pregnant women with PIH.The disorders of coagulation function may be more severe in early onset preeelampsia than those in late onset preeclampsia.
