CAJ | 학술논문

目的探讨丙型肝炎患者肝外组织丙型肝炎病毒(HCV)感染状态、致病性及其意义.方法采用免疫组化法检测9例重型丙型肝炎患者肾、心、胰腺和肠等肝外组织内HCV多种抗原表达,并观察各组织病理改变.结果 9例中6例(66.7%)在肝外组织检出HCV抗原.抗原定位于细胞浆内,呈均质型、包涵体型和膜下型.组织内抗原表达阳性细胞数量较少,不同组织间阳性细胞种类、数量和分布略有差异.病理学观察未发现细胞内HCV抗原阳性表达与组织病变有明确相关性.结论 HCV可以感染肝外组织,但未显示显著致病性.作为致病因子的HCV持续存在肝外多种脏器细胞内,在丙型肝炎慢性化和干扰素治疗后病情复发中可能起重要作用.
목적 탐토병형간염환자간외조직병형간염병독(HCV)감염상태、치병성급기의의.방법 채용면역조화법검측9례중형병형간염환자신、심、이선화장등간외조직내HCV다충항원표체,병관찰각조직병리개변.결과 9례중6례(66.7%)재간외조직검출HCV항원.항원정위우세포장내,정균질형、포함체형화막하형.조직내항원표체양성세포수량교소,불동조직간양성세포충류、수량화분포략유차이.병이학관찰미발현세포내HCV항원양성표체여조직병변유명학상관성.결론 HCV가이감염간외조직,단미현시현저치병성.작위치병인자적HCV지속존재간외다충장기세포내,재병형간염만성화화간우소치료후병정복발중가능기중요작용.
Objective To explore the state of extrahepatic hepatitis C virus(HCV)infection,viral pathogenicity and its significance in hepatitis C patients.Methods Immunohistochemical assay was used to examine the expression of various HCV antigens in the kidney,heart,pancreas and intestine from 9 severe hepatitis C patients.Relationship between the expression of HCV antigens and tissue lesions was evaluated.Results HCV antigens in extrahepatic tissues were detected in 6 of 9(66.7%)hepatitis C patients and the expression of HCV antigens was observed only within cytoplasm in the style of homogenous,inclusion and submembrane distribution.The amount of positive-staining cells was less in the tissue and there were a few differences of kind,amount and distribution of HCV antigens-positive-staining cells among different extrahepatic tissues.There was no relationship between the expression of HCV antigens and tissue lesion.Conclusions These results show that HCV exists in different extrahepatic tissues,but do not bring out obvioklS cell injury.As a etiologic agent,the persistence of HCV in extrahepatic tissues may take an important role in the relapse as well as the chronicity of hepatitis C after discontinuation of interferon therapy.