CAJ | 학술논문

目的探讨妊娠期暴发型肝功能衰竭(FHFP)的临床,生化,病原学特点.方法观察21例FHFP临床表现,并分析实验室资料,13例作肝组织学检查.结果乙型肝炎病毒感染7例,乙型肝炎病毒、戊型肝炎病毒重叠感染2例.FHFP血清白蛋白极显著低于妊娠期急性肝炎和慢性肝炎.分别为(25.19±6.95)、(33.17±3.44)及(33.80±3.78)g/L(均P<0.01).肝组织学诊断为,存活的6例中,急性肝炎1例,慢性肝炎4例,瘀胆型肝炎1例.死亡7例中,慢性肝炎4例,瘀胆型肝炎2例,产前子痫肝损害1例.结论肝炎病毒是FHFP的病因之一.低蛋白血症在FHFP发病中起着重要作用;FHFP可能是一种独特的综合征.
목적 탐토임신기폭발형간공능쇠갈(FHFP)적림상,생화,병원학특점.방법 관찰21례FHFP림상표현,병분석실험실자료,13례작간조직학검사.결과 을형간염병독감염7례,을형간염병독、무형간염병독중첩감염2례.FHFP혈청백단백겁현저저우임신기급성간염화만성간염.분별위(25.19±6.95)、(33.17±3.44)급(33.80±3.78)g/L(균P<0.01).간조직학진단위,존활적6례중,급성간염1례,만성간염4례,어담형간염1례.사망7례중,만성간염4례,어담형간염2례,산전자간간손해1례.결론 간염병독시FHFP적병인지일.저단백혈증재FHFP발병중기착중요작용;FHFP가능시일충독특적종합정.
Objective To study the clinical,biochemical and serological profiles of fulminan hepaticfailure during pregnancy(FHFP).Methods Clinical and laboratory data were analyzed in 21 patients withFHFP.HeDatic biopsies were undertaken in 13 cases.Results The results of serologic tests showed that 7cases were infected by hepatitis B alone and other 2 cases were superinfected with hepatitis B and hepatitis Evirus.ResuIts of liver function tests showed levels of serum albumin in FHFP patients were signifieantly lower than those in the patients with chronic hepatitis and acute hepatitis during pregnancy ( both P<0.01).Seven died patients were histopathologieally diagnosed as chronic hepatitis in 4,cholestatic hePatitis in 2, and pre-eclampsia induced liver lesion in 1 respectively. Among 6 survivlors, 1 acute hepatitis, 4chronic hepatitis and 1 cholestatic hepatitis were found.Conclusion Hepatitis virus is one of etiological tactors contributing to FHFP. Severe hypoalbuminemia may play an important role in the pathogenesis of FHFP.FHFP may be defined as an unique syndrome in the infections of hepatitis virus.