中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
13期
1735-1736
,共2页
脑梗死%血管内皮生长因子A%基质金属蛋白酶9
腦梗死%血管內皮生長因子A%基質金屬蛋白酶9
뇌경사%혈관내피생장인자A%기질금속단백매9
Brain infarction%Vascular endothelial growth factor A%Matrix metalloproteinase 9
目的 研究血清血管内皮生长因子(VEGF)和基质金属蛋白酶9(MMP-9)含量的动态变化在脑梗死治疗和预后判断中的意义.方法 选取123例急性脑梗死患者为观察组,80例健康体检者为对照组.分别于发病后1、3、5、7、14 d时对急性脑梗死患者进行血清VEGF和MMP-9含量检测,并研究其与患者梗死面积和预后的相关性.结果 发病后1、3、5、7、14 d时血清VEGF和MMP-9的含量呈现一种先升后降的状态,但观察组均显著高于对照组(P＜0.01).预后不良患者在发病后各时段血清VEGF[(369.3±108.7),(476.2±118.4),(551.5±144.5),(661.7±164.6),(437.6±123.9)ng/L]和MMP-9[(333.8±101.4),(459.7±119.9),(370.3±119.5),(320.5±129.1),(255.4±101.6)ng/L]含量均明显高于预后良好者(均P＜0.01).结论 急性脑梗死患者血清中VEGF和MMP-9含量均呈现一种动态的变化状态,且与梗死面积及预后呈现一种较为紧密的关系.
目的 研究血清血管內皮生長因子(VEGF)和基質金屬蛋白酶9(MMP-9)含量的動態變化在腦梗死治療和預後判斷中的意義.方法 選取123例急性腦梗死患者為觀察組,80例健康體檢者為對照組.分彆于髮病後1、3、5、7、14 d時對急性腦梗死患者進行血清VEGF和MMP-9含量檢測,併研究其與患者梗死麵積和預後的相關性.結果 髮病後1、3、5、7、14 d時血清VEGF和MMP-9的含量呈現一種先升後降的狀態,但觀察組均顯著高于對照組(P＜0.01).預後不良患者在髮病後各時段血清VEGF[(369.3±108.7),(476.2±118.4),(551.5±144.5),(661.7±164.6),(437.6±123.9)ng/L]和MMP-9[(333.8±101.4),(459.7±119.9),(370.3±119.5),(320.5±129.1),(255.4±101.6)ng/L]含量均明顯高于預後良好者(均P＜0.01).結論 急性腦梗死患者血清中VEGF和MMP-9含量均呈現一種動態的變化狀態,且與梗死麵積及預後呈現一種較為緊密的關繫.
목적 연구혈청혈관내피생장인자(VEGF)화기질금속단백매9(MMP-9)함량적동태변화재뇌경사치료화예후판단중적의의.방법 선취123례급성뇌경사환자위관찰조,80례건강체검자위대조조.분별우발병후1、3、5、7、14 d시대급성뇌경사환자진행혈청VEGF화MMP-9함량검측,병연구기여환자경사면적화예후적상관성.결과 발병후1、3、5、7、14 d시혈청VEGF화MMP-9적함량정현일충선승후강적상태,단관찰조균현저고우대조조(P＜0.01).예후불량환자재발병후각시단혈청VEGF[(369.3±108.7),(476.2±118.4),(551.5±144.5),(661.7±164.6),(437.6±123.9)ng/L]화MMP-9[(333.8±101.4),(459.7±119.9),(370.3±119.5),(320.5±129.1),(255.4±101.6)ng/L]함량균명현고우예후량호자(균P＜0.01).결론 급성뇌경사환자혈청중VEGF화MMP-9함량균정현일충동태적변화상태,차여경사면적급예후정현일충교위긴밀적관계.
Objective To study the significance on dynamic changes of serum vascular endothelial growth factor( VECF) and matrix metalloproteinase 9( MMP-9) in patients with acute cerebral infarction. Methods 123 patients with acute cerebral infarction were selected as research object, and they were the observation group, and 80 healthy peoples at the same time were selected as control group. Then the serum VEGF and MMP-9 in patients with acute cerebral infarction after pathogenesis at first,third,fifth,seventh and fourteenth day were detected,and the correction between the levels and infarct size,prognosis were studied. Results The serum VECF and MMP-9 of observation group compared with those of control group,the change showed increased first and decreased afterwards,but the levels were all higher than those of control group (P ＜ 0.01). There were correction between the levels and infarct size, prognosis.The serum VEGF[(369.3 ± 108.7,476.2 ± 118.4,551.5 ± 144.5,661.7 ± 164.6,437.6 ± 123.9)ng/L]and MMP-9[(333.8±101.4,459.7±119.9,370.3 ±119.5,320.5 ± 129.1,255.4 ± 101.6)ng/L] in poor prognosis patients after pathogenesis at first,third,fifth,seventh and fourteenth day were all higher than those of good prognosis patients ( P ＜0.01). Conclusion The serum VEGF and MMP-9 in patients with acute cerebral infarction showed dynamic change,and there was close relationship between the levels and infarct size.
