国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2012年
5期
291-293,302
,共4页
星状神经节阻滞%原发性痛经%视觉模拟评分%睡眠影响指数
星狀神經節阻滯%原髮性痛經%視覺模擬評分%睡眠影響指數
성상신경절조체%원발성통경%시각모의평분%수면영향지수
Stellate ganglion block%Primary dysmenorrhea%Visual analog scale%Sleep interference scale
目的 探讨星状神经节阻滞(stellate ganglion block,SGB)对原发性痛经(primary dysmenorrheal,PD)的治疗效果及其作用机制.方法 选择2007年10月-2011年6月,某医学院校护理学专业PD患者76例,采用SGB治疗.于行经前7d开始,月经来潮3d后停止,每日1次,左右交替进行,共治疗3个月经周期,即3个疗程.比较治疗开始前上次月经来潮24h内(T0)、第1疗程月经来潮24h内(T1)、第2疗程月经来潮24 h内(T2)、第3疗程月经来潮24h内(T3)、第3疗程结束后3个月月经来潮24 h内(T4)的视觉模拟评分法(visual analog scale,VAS)评分,睡眠影响指数(sleep interference scale,SIS)变化,同时于以上各时点静脉采血,酶联免疫吸附法(ELISA)测定血清前列腺素F2α(prostaglandin F2α,PGF2α)浓度、前列腺素F2α/前列腺素E2(prostaglandin F2α/prostaglandin E2,PGF2α/PGE2)比值.结果 T1、T2、T3、T4 VAS分别为(1.83±0.52)、(1.48±0.21)、(1.25±0.14)、(1.30±0.25),与T0(6.35±1.42)比较,明显降低,差异有统计学意义(P＜0.01).T1、T2、T3、T4 SIS分别为(1.52±0.41)、(1.40±0.22)、(1.12±0.11)、(1.33±0.24),与T0(6.55±1.32)比较,明显降低,差异有统计学意义(P＜0.01).T1、T2、T3、T4血清PGF2α分别为(5.1±1.1)、(4.9±1.2)、(4.8±1.6)、(4.9±1.7)μg/L,与T0(15.3 ±2.1)μg/L比较,差异有统计学意义(P＜0.05).T1、T2、T3、T4血清PGF2α/PGE2比值分别为(2.1±1.3)、(1.9±1.4)、(1.8±1.1)、(2.1±1.3),与T0(5.2±1.6)比较,差异有统计学意义(P＜0.05).结论 SGB治疗PD,具有降低疼痛、改善睡眠的临床效果,疗效相对稳定,其作用机制可能与SGB降低经期血清PGF2α浓度、PGF2α/PGE2比值有关.
目的 探討星狀神經節阻滯(stellate ganglion block,SGB)對原髮性痛經(primary dysmenorrheal,PD)的治療效果及其作用機製.方法 選擇2007年10月-2011年6月,某醫學院校護理學專業PD患者76例,採用SGB治療.于行經前7d開始,月經來潮3d後停止,每日1次,左右交替進行,共治療3箇月經週期,即3箇療程.比較治療開始前上次月經來潮24h內(T0)、第1療程月經來潮24h內(T1)、第2療程月經來潮24 h內(T2)、第3療程月經來潮24h內(T3)、第3療程結束後3箇月月經來潮24 h內(T4)的視覺模擬評分法(visual analog scale,VAS)評分,睡眠影響指數(sleep interference scale,SIS)變化,同時于以上各時點靜脈採血,酶聯免疫吸附法(ELISA)測定血清前列腺素F2α(prostaglandin F2α,PGF2α)濃度、前列腺素F2α/前列腺素E2(prostaglandin F2α/prostaglandin E2,PGF2α/PGE2)比值.結果 T1、T2、T3、T4 VAS分彆為(1.83±0.52)、(1.48±0.21)、(1.25±0.14)、(1.30±0.25),與T0(6.35±1.42)比較,明顯降低,差異有統計學意義(P＜0.01).T1、T2、T3、T4 SIS分彆為(1.52±0.41)、(1.40±0.22)、(1.12±0.11)、(1.33±0.24),與T0(6.55±1.32)比較,明顯降低,差異有統計學意義(P＜0.01).T1、T2、T3、T4血清PGF2α分彆為(5.1±1.1)、(4.9±1.2)、(4.8±1.6)、(4.9±1.7)μg/L,與T0(15.3 ±2.1)μg/L比較,差異有統計學意義(P＜0.05).T1、T2、T3、T4血清PGF2α/PGE2比值分彆為(2.1±1.3)、(1.9±1.4)、(1.8±1.1)、(2.1±1.3),與T0(5.2±1.6)比較,差異有統計學意義(P＜0.05).結論 SGB治療PD,具有降低疼痛、改善睡眠的臨床效果,療效相對穩定,其作用機製可能與SGB降低經期血清PGF2α濃度、PGF2α/PGE2比值有關.
목적 탐토성상신경절조체(stellate ganglion block,SGB)대원발성통경(primary dysmenorrheal,PD)적치료효과급기작용궤제.방법 선택2007년10월-2011년6월,모의학원교호이학전업PD환자76례,채용SGB치료.우행경전7d개시,월경래조3d후정지,매일1차,좌우교체진행,공치료3개월경주기,즉3개료정.비교치료개시전상차월경래조24h내(T0)、제1료정월경래조24h내(T1)、제2료정월경래조24 h내(T2)、제3료정월경래조24h내(T3)、제3료정결속후3개월월경래조24 h내(T4)적시각모의평분법(visual analog scale,VAS)평분,수면영향지수(sleep interference scale,SIS)변화,동시우이상각시점정맥채혈,매련면역흡부법(ELISA)측정혈청전렬선소F2α(prostaglandin F2α,PGF2α)농도、전렬선소F2α/전렬선소E2(prostaglandin F2α/prostaglandin E2,PGF2α/PGE2)비치.결과 T1、T2、T3、T4 VAS분별위(1.83±0.52)、(1.48±0.21)、(1.25±0.14)、(1.30±0.25),여T0(6.35±1.42)비교,명현강저,차이유통계학의의(P＜0.01).T1、T2、T3、T4 SIS분별위(1.52±0.41)、(1.40±0.22)、(1.12±0.11)、(1.33±0.24),여T0(6.55±1.32)비교,명현강저,차이유통계학의의(P＜0.01).T1、T2、T3、T4혈청PGF2α분별위(5.1±1.1)、(4.9±1.2)、(4.8±1.6)、(4.9±1.7)μg/L,여T0(15.3 ±2.1)μg/L비교,차이유통계학의의(P＜0.05).T1、T2、T3、T4혈청PGF2α/PGE2비치분별위(2.1±1.3)、(1.9±1.4)、(1.8±1.1)、(2.1±1.3),여T0(5.2±1.6)비교,차이유통계학의의(P＜0.05).결론 SGB치료PD,구유강저동통、개선수면적림상효과,료효상대은정,기작용궤제가능여SGB강저경기혈청PGF2α농도、PGF2α/PGE2비치유관.
Objective To investigate the efficacy of stellate ganglion block (SGB) as treatment in primary dysmenorrheal (PD) patients and the possible mechanism. Methods A total of 76 PD patients were referred to our clinic from October 2007 to June 2011.All of them received SGB switching from left to right ganglion once daily from 7 days before through 3 days after menstrual period in 3 consecutive menstruation cycles.The visual analog scale (VAS) and sleep interference scale (SIS) were recorded within 24 hours after the last untreated menstruation (T0),the 1st treated menstruation (T1),the 2nd treated menstruation (T2),the 3rd treated menstruation (T3),and the 3rd menstruation after treatment (T4),respectively.In addition,the serum prostaglandin F2α (PGF2α) level and prostaglandin F2α/prostaglandin E2 (FGE2α/FGE2)ratio were measured at the above time points.Results The VAS scores at T1,T2,T3 and T4 were (1.83±0.52),(1.48±0.21),(1.25±0.14),(1.30±0.25),respectively,which were significantly less than that at T0 (6.35±1.42)(P＜0.01 ).The SIS scores at T1,T2,T3 and T4 were (1.52±0.41),(1.40±0.22),(1.12±0.11),( 1.33±0.24),respectively,which were significantly less than that at T0 (6.55±1.32) (P＜0.01).The serum PGF2α and PGF2α/PGE2 ratio at T1,T2,T3 and T4 were(5.1±1.1 ) μg/L and (2.1±1.3),(4.9±1.2),(1.9±1.4),(4.8±1.6) μg/L,(1.8±1.1),(4.9±1.7) μg/L and (2.1±1.3),respectively,which were significantly less than that at T0 (15.3±2.1),(5.2±1.6) (P＜0.01). Conclusions SGB is effective in pain relief and sleep improvement for PD patient,which may be associated with the reduction of serum PGF2α level and PGF2α/PGE2 ratio.
