国际护理学杂志
國際護理學雜誌
국제호이학잡지
INTERNATIONAL JOURNAL OF NURSING
2011年
6期
946-948
,共3页
螺旋藻多糖%新生血管%Lewis肺癌%小鼠
螺鏇藻多糖%新生血管%Lewis肺癌%小鼠
라선조다당%신생혈관%Lewis폐암%소서
Polysaccharide%Neovascular%Lewis lung cancer%Mice
目的 探讨螺旋藻多糖对小鼠Lewis肺癌的抑制作用.方法 C57BL/6小鼠45只,随机分为螺旋藻多糖治疗组、预防组及空白对照组,每组15只.对照组每只小鼠右后肢背部皮下接种1×106 Lewis肺癌细胞,待瘤体直径达5 mm时瘤内多点注射0.9%生理盐水100 mg/kg,每天1次,连续3 w;预防组给小鼠接种肿瘤细胞前1 w每天腹腔注射PSP 100 mg/kg,每天1次,1 w后,每只小鼠右后肢背部皮下接种1×106 Lewis肺癌细胞,待瘤体直径达5 mm时瘤内多点注射PSP 100 mg/kg,每天1次,连续3 w;PSP组首先于右后肢背部皮下接种1×106 Lewis肺癌细胞,待瘤体直径达5 mm时瘤内多点注射PSP 100 mg/kg,每天1次,连续3 w.结果 螺旋藻多糖治疗组、预防组与对照组相比较,肿瘤生长速度减慢,新生血管数量减少,肿瘤细胞凋亡增加,增殖减慢.结论 螺旋藻多糖对小鼠Lewis肺癌的生长具有一定的抑制作用.
目的 探討螺鏇藻多糖對小鼠Lewis肺癌的抑製作用.方法 C57BL/6小鼠45隻,隨機分為螺鏇藻多糖治療組、預防組及空白對照組,每組15隻.對照組每隻小鼠右後肢揹部皮下接種1×106 Lewis肺癌細胞,待瘤體直徑達5 mm時瘤內多點註射0.9%生理鹽水100 mg/kg,每天1次,連續3 w;預防組給小鼠接種腫瘤細胞前1 w每天腹腔註射PSP 100 mg/kg,每天1次,1 w後,每隻小鼠右後肢揹部皮下接種1×106 Lewis肺癌細胞,待瘤體直徑達5 mm時瘤內多點註射PSP 100 mg/kg,每天1次,連續3 w;PSP組首先于右後肢揹部皮下接種1×106 Lewis肺癌細胞,待瘤體直徑達5 mm時瘤內多點註射PSP 100 mg/kg,每天1次,連續3 w.結果 螺鏇藻多糖治療組、預防組與對照組相比較,腫瘤生長速度減慢,新生血管數量減少,腫瘤細胞凋亡增加,增殖減慢.結論 螺鏇藻多糖對小鼠Lewis肺癌的生長具有一定的抑製作用.
목적 탐토라선조다당대소서Lewis폐암적억제작용.방법 C57BL/6소서45지,수궤분위라선조다당치료조、예방조급공백대조조,매조15지.대조조매지소서우후지배부피하접충1×106 Lewis폐암세포,대류체직경체5 mm시류내다점주사0.9%생리염수100 mg/kg,매천1차,련속3 w;예방조급소서접충종류세포전1 w매천복강주사PSP 100 mg/kg,매천1차,1 w후,매지소서우후지배부피하접충1×106 Lewis폐암세포,대류체직경체5 mm시류내다점주사PSP 100 mg/kg,매천1차,련속3 w;PSP조수선우우후지배부피하접충1×106 Lewis폐암세포,대류체직경체5 mm시류내다점주사PSP 100 mg/kg,매천1차,련속3 w.결과 라선조다당치료조、예방조여대조조상비교,종류생장속도감만,신생혈관수량감소,종류세포조망증가,증식감만.결론 라선조다당대소서Lewis폐암적생장구유일정적억제작용.
Objective To study the inhibition effect of the polysaccharides on the mouse Lewis lung cancer.Methods The mouse Lewis lung cancer model was established, then the polysaccharides according to 100 mg/kg once a day were injected to the mouses' abdominal cavity, the inhibition effect on the mouse lung cancer was assessed.Results Compared with the blank group, tumor growth velocity of the polysaccharides group and prevention group stepped down, the neovascular grew downwards, tumor cell apoptosis increased, proliferation stepped down.Conclusions Polysaccharides have inhibition effect on the mouse Lewis lung cancer.
