CAJ | 학술논문

目的探讨高压氧治疗新生儿缺氧缺血性脑病(HIE)的临床疗效及期对预后的影响.方法根据是否进行高压氧治疗随机分为两组,高压氧组203例,对照组98例;两组综合治疗措施相同.高压氧治疗方法是按病情分时期进行.两组分别于生后第2、7、14天做3次行为神经测定(NBNA)以及动态系列各项检测以评价其近期疗效;远期随访至2～5岁的预后转归.结果以总有效率比较,高压氧组疗效明显优于对照组(P＜0.005);高压氧组生后第7、14天的NBNA评分均明显高于对照组(P＜0.05～0.01);生后2个月头颅CT复查比较,高压氧组发生长久性脑损害较对照组明显减少(P＜0.01);以预后不良率比较,高压氧组为9.36%,对照组为25.51%,差异显著(P＜0.01).结论高压氧治疗HIE的近期临床疗效显著,远期预后转归明显改善.按病情分时期进行治疗比较适宜和安全.
목적탐토고압양치료신생인결양결혈성뇌병(HIE)적림상료효급기대예후적영향.방법근거시부진행고압양치료수궤분위량조,고압양조203례,대조조98례;량조종합치료조시상동.고압양치료방법시안병정분시기진행.량조분별우생후제2、7、14천주3차행위신경측정(NBNA)이급동태계렬각항검측이평개기근기료효;원기수방지2～5세적예후전귀.결과이총유효솔비교,고압양조료효명현우우대조조(P＜0.005);고압양조생후제7、14천적NBNA평분균명현고우대조조(P＜0.05～0.01);생후2개월두로CT복사비교,고압양조발생장구성뇌손해교대조조명현감소(P＜0.01);이예후불량솔비교,고압양조위9.36%,대조조위25.51%,차이현저(P＜0.01).결론고압양치료HIE적근기림상료효현저,원기예후전귀명현개선.안병정분시기진행치료비교괄의화안전.
Objective: To evaluate the clinical efficacy and prognosis of the hyperbaric oxygen in treatment of neonatal hypoxic-ischemic encephalopathy(HIE). Methods: 301 neonates with HIE were randomly divided into two two groups (treated group 203 neonates, control group 98 neonates), the treated group received hyperbaric oxygen therapeusis at different time based on neonatal conditions. The two groups received 3 times NBNA marks measured (at the 2nd, 7th, 14th day after birth), and other series measured to evaluate short-term efficacy. The two groups were followed up 2～5 years to evaluate their long-term efficacy. Results: The general effective rate of the treated group was significantly higher than that of control group (P ＜0.05); The NBNA marks of the treated group (at the 7th, 14th day after birth) obviously increased (P ＜0.05), and long-term brain damage (based on brain CT results of two months) obviously decreased (P ＜0.01). The unfavorable prognosis rate in treated group (9.36%) was lower than that of control group (25.51%). Conclusion: Hyperbaric oxygen has a markedly short-term therapeutic effect on neonates with HIE and significantly improves the prognosis of the neonates. It is relatively safe and suitable in treating the neonates with HIE at different time based on neonatal conditions.